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HDAC1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS477133

Entrez Summary: Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Product Overview

Product Name
HDAC1, Polyclonal Antibody
Full Product Name
Anti-HDAC1 Rabbit pAb
Product Gene Name
anti-HDAC1 antibody
Product Synonym Gene Name
HD1; RPD3; GON-10; RPD3L1
Product Synonym Names
DKFZp686H12203; GON 10; HD 1; HD1; HDAC 1; HDAC1; hdac1: histone deacetylase 1; HDAC1_HUMAN; Histone deacetylase 1 (HD1); Histone deacetylase 1; Reduced potassium dependency yeast homolog like 1; RPD3 (reduced potassium dependency yeast homolog) like 1; RPD3 (reduced potassium dependency); RPD3; RPD3L1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Source: Human
Species Reactivity
Human, Mouse, Rat
Sensitivity
This antibody detects endogenous levels of HDAC1 and does not cross-react with related proteins.
Form/Format
10mM PBS with 0.02% sodium azide, 50% glycerol.
Purity/Purification
Affinity Purified
Molecular Weight
55
OMIM
U50079 mRNA
3D Structure
ModBase 3D Structure for Q13547
Immunogen
The antiserum was produced against synthesized non-phosphopeptide derived from human HDAC1 around the phosphorylation site of serine 421/423.
Sequence Similarities
Belongs to the histone deacetylase family. HD type 1 subfamily.
Subunit Structure
Interacts with C10orf90/FATS (via its N-terminal): the interaction prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21. Interacts with CDKN1A/p21; the interaction is prevented by binding of C10orf90/FATS facilitating acetylation and stabilization of CDKN1A/p21. Component of a RCOR/GFI/KDM1A/HDAC complex. Interacts directly with GFI1 and GFI1B. Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates with MTA2, MBD2, MBD3, MTA1L1, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex, or with SIN3, SAP18 and SAP30 to form the SIN3 HDAC complex. Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Associates with the 9-1-1 complex; interacts with HUS1. Found in a complex with DNMT3A and HDAC7. Interacts with BAZ2A/TIP5, BCOR, BRMS1L, DAXX, DNMT1, EP300, HCFC1, NFE4, PCAF, PHB2, MIER1, KDM4A, MINT, NRIP1, PRDM6, RERE, SETDB1, SMYD2, SUV39H1, TGIF, TGIF2, UHRF1, UHRF2 and ZNF541. Interacts with the non-histone region of H2AFY. Interacts with HDAC9. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Interacts with BANP, CBFA2T3 and KDM5B. Interacts with SAP30L. Interacts with E4F1. Interacts with KFL1 and SAMSN1. Interacts with SV40 large T antigen. Interacts with CHFR, PRDM16 and SMAD3. Interacts with SP1; the interaction deacetylates SP1 and regulates its transcriptional activity. Interacts with SP3; the interaction deacetylates SP3 and regulates its transcriptional activity. In vitro, C18 ceramides increase this interaction and the subsequent SP3 deacetylation and SP3-mediated repression of the TERT promoter. Interacts with RB1 and SMARCA4/BRG1. Interacts with TRAF6. Interacts with TSHZ3 (via N-terminus); the interaction is direct. Found in a trimeric complex with APBB1 and TSHZ3; the interaction between HDAC1 and APBB1 is mediated by TSHZ3. Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1. Interacts with NR4A2/NURR1 and BRMS1. Interacts with TRIM28; the interaction recruits HDAC1 to E2F1 and inhibits its acetylation. Binds to CDK5 complexed to CDK5R1 (p25). Interacts with ZMYND15. Interacts with DDX5. Part of a complex composed of TRIM28, HDAC1, HDAC2 and EHMT2. Interacts with BCL6 and DDIT3/CHOP. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2.
Subcellular Location
Nucleus.
Applications Tested/Suitable for anti-HDAC1 antibody
Western Blot (WB), Immunohistochemistry (IHC)

Immunohistochemistry (IHC) of anti-HDAC1 antibody

Immunohistochemical analysis of paraffin- embedded human lung adenocarcinoma tissue using HDAC1 (Ab-421/423) Antibody.
Rabbit Anti-HDAC1 Polyclonal Antibody – Cat# MBS477133

Other Notes

Small volumes of anti-HDAC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HDAC1 purchase

MBS477133 is an antibody targeting HDAC1. Also known as Anti-HDAC1 Rabbit pAb. Reactive in Human, Mouse, Rat. Host: Rabbit
Source: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for HDAC1. It may not necessarily be applicable to this product.

NCBI GI #
13128860
NCBI GeneID
3065
NCBI Accession #
NP_004955.2
UniProt Primary Accession #
Q13547
UniProt Secondary Accession #
Q92534
UniProt Related Accession #
Q13547
GenBank Nucleotide #
NM_004964.2
NCBI Official Full Name
histone deacetylase 1
NCBI Official Synonym Full Names
histone deacetylase 1
NCBI Official Symbol
HDAC1
NCBI Official Synonym Symbols
HD1; RPD3; GON-10; RPD3L1
UniProt Protein Name
Histone deacetylase 1
Protein Family
Msx2-interacting protein
UniProt Gene Name
HDAC1
UniProt Synonym Gene Names
RPD3L1; HD1
NCBI Protein Information
histone deacetylase 1

NCBI Summary for HDAC1

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]
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UniProt Comments for HDAC1

HDAC1: a transcriptional regulator of the histone deacetylase family, subfamily 1. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein type: EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 1p35.2-p35.1

Cellular Component: chromatin; cytoplasm; cytosol; histone deacetylase complex; nuclear chromatin; nucleoplasm; nucleus; NuRD complex; protein complex; Sin3 complex

Molecular Function: deacetylase activity; enzyme binding; histone deacetylase activity; histone deacetylase binding; NF-kappaB binding; nucleosomal DNA binding; protein binding; protein deacetylase activity; protein N-terminus binding; transcription activator binding; transcription factor activity; transcription factor binding

Biological Process: ATP-dependent chromatin remodeling; blood coagulation; chromatin remodeling; circadian regulation of gene expression; embryonic digit morphogenesis; epidermal cell differentiation; establishment and/or maintenance of chromatin architecture; histone deacetylation; methylation-dependent chromatin silencing; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; odontogenesis of dentine-containing teeth; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid deacetylation
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Research Articles on HDAC1

1. HDAC1 expression in TE-1, Eca109 and EC9706 cells was significantly higher compared with normal esophageal cell line HEEC.The siRNA-mediated HDAC1 knockdown significantly inhibited the proliferation, migration and invasion of TE-1 cells probably by regulating the expression of cell cycle- and EMT-related proteins.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HDAC1 antibody

 Reference Product  PubMed Publications
 HDAC2 antibody  >376 publications with HDAC1 and HDAC2
 HDAC3 antibody  >166 publications with HDAC1 and HDAC3
 SP1 antibody  >96 publications with HDAC1 and SP1
 CDKN1A antibody  >95 publications with HDAC1 and CDKN1A
 DNMT1 antibody  >80 publications with HDAC1 and DNMT1
 SIN3A antibody  >78 publications with HDAC1 and SIN3A
 RELA antibody  >36 publications with HDAC1 and RELA
 DNMT3A antibody  >35 publications with HDAC1 and DNMT3A
 SP3 antibody  >31 publications with HDAC1 and SP3
 DNMT3B antibody  >31 publications with HDAC1 and DNMT3B

Pathways associated with anti-HDAC1 antibody

 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram

Diseases associated with anti-HDAC1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >472 publications with HDAC1 and Neoplasms
 Breast Neoplasms Antibodies  >78 publications with HDAC1 and Breast Neoplasms
 Nervous System Diseases Antibodies  >51 publications with HDAC1 and Nervous System Diseases
 Necrosis Antibodies  >48 publications with HDAC1 and Necrosis
 Inflammation Antibodies  >47 publications with HDAC1 and Inflammation
 Liver Diseases Antibodies  >41 publications with HDAC1 and Liver Diseases
 Liver Neoplasms Antibodies  >35 publications with HDAC1 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >35 publications with HDAC1 and Carcinoma, Hepatocellular
 Neoplasm Metastasis Antibodies  >34 publications with HDAC1 and Neoplasm Metastasis
 Cell Transformation, Neoplastic Antibodies  >32 publications with HDAC1 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-HDAC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >98 publications with HDAC1 and Blood
 Liver Antibodies  >94 publications with HDAC1 and Liver
 Brain Antibodies  >93 publications with HDAC1 and Brain
 Lung Antibodies  >76 publications with HDAC1 and Lung
 Prostate Antibodies  >59 publications with HDAC1 and Prostate
 Muscle Antibodies  >56 publications with HDAC1 and Muscle
 Kidney Antibodies  >41 publications with HDAC1 and Kidney
 Bone Antibodies  >38 publications with HDAC1 and Bone
 Heart Antibodies  >34 publications with HDAC1 and Heart
 Embryonic Tissue Antibodies  >30 publications with HDAC1 and Embryonic Tissue
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