mTOR Antibody – Rabbit Polyclonal

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]

mTOR: an atypical kinase belonging to the PIKK family of kinases. Is the catalytic subunit of two protein complexes, mTORC1 and mTORC2. mTORC1 activates S6K and inactivates 4E-BP1, up-regulating protein synthesis. mTORC1 contains Raptor, a positive regulatory subunit and scaffold for recruiting substrates, two negative regulators, PRAS40 and DEPTOR, and mLST8; it is a target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. mTORC2, a downstream effector of PI3K, is insensitive to rapamycin and activates Akt by phosphorylating a key activation site. mTORC2 contains regulatory subunits Rictor and mSIN1, PROTOR, mLST8, and the negative regulator DEPTOR. mTORC1 suppresses PI3K activity via a strong negative feedback loop that involves S6K1. Inhibiting mTORC1 ablates this negative feedback loop and potentiates PI3K signaling. Known inhibitors of mTOR include rapamycin, temsirolimus (CCI-779).

Protein type: ATYPICAL group; Autophagy; EC 2.7.11.1; FRAP subfamily; Kinase, protein; Motility/polarity/chemotaxis; PIKK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: cytoplasm; cytosol; endomembrane system; lysosomal membrane; lysosome; membrane; nucleoplasm; nucleus; PML body; TORC2 complex

Molecular Function: kinase activity; phosphoprotein binding; protein binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: autophagy; cell cycle arrest; cell growth; cellular response to nutrient levels; DNA repair; macroautophagy; negative regulation of autophagy; peptidyl-serine phosphorylation; phosphoinositide-mediated signaling; phosphorylation; positive regulation of lipid biosynthetic process; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase III promoter; positive regulation of translation; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein catabolic process; regulation of actin cytoskeleton organization and biogenesis; regulation of osteoclast differentiation; response to amino acid stimulus; response to stress; T cell costimulation; TOR signaling pathway

Disease: Smith-kingsmore Syndrome