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HDAC2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS477377

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle… More details

$525 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
HDAC2, Monoclonal Antibody
Full Product Name
Anti-HDAC2 Mouse mAb
Product Gene Name
anti-HDAC2 antibody
Product Synonym Gene Name
HD2; RPD3; YAF1; HDAC2
Product Synonym Names
D10Wsu179e; HD 2; HD2; HDAC 2; Hdac2; HDAC2_HUMAN; Histone deacetylase 2 (HD2); Histone deacetylase 2; OTTHUMP00000017046; OTTHUMP00000227077; OTTHUMP00000227078; RPD3; transcriptional regulator homolog RPD3; YAF1; YY1 associated factor 1; YY1 transcription factor binding protein; Yy1bp
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
2D9-F6-G7
Host
Mouse
Species Reactivity
Human, Mouse, Rat, Monkey
Form/Format
PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
Purity/Purification
Affinity Purified
Specificity
This antibody detects endogenous levels of HDAC2 and does not cross-react with related proteins.
Preparation and Storage
Store at 4 degree C for short term.
Store at-20 degree C for long term.
Avoid freeze/thaw cycle.
Molecular Weight
60kDa
OMIM
605164
3D Structure
ModBase 3D Structure for Q92769
Immunogen
Purified recombinant human HDAC2 protein fragments expressed in E.coli.
Subcellular Location
Nucleus
Applications Tested/Suitable for anti-HDAC2 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-HDAC2 antibody
WB: 1:1000

Western Blot (WB) of anti-HDAC2 antibody

Western blot detection of HDAC2 in THP-1, SHSY-5Y, K562, COS7, C6, 3T3 and Hela cell lysates using HDAC2 mouse mAb(dilution 1:1000).Predicted band size:60kDa.Observed band size:60kDa.
Mouse Anti-HDAC2 Monoclonal Antibody – Cat# MBS477377

Immunocytochemistry (ICC) of anti-HDAC2 antibody

Immunocytochemistry staining of HeLa cells fixed with-20 degree C Methanol and using HDAC2 (MBS477377, dilution 1:200) mouse mAb (green).
Mouse Anti-HDAC2 Monoclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS477377

Other Notes

Small volumes of anti-HDAC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HDAC2 purchase

MBS477377 is an antibody targeting HDAC2. Also known as Anti-HDAC2 Mouse mAb. Reactive in Human, Mouse, Rat, Monkey. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for HDAC2. It may not necessarily be applicable to this product.

NCBI GI #
293336691
NCBI GeneID
3066
NCBI Accession #
NP_001518.3
UniProt Primary Accession #
Q92769
UniProt Secondary Accession #
Q5SRI8; Q5SZ86; Q8NEH4; B3KRS5; B4DL58; E1P561
UniProt Related Accession #
Q92769
GenBank Nucleotide #
NM_001527.3
NCBI Official Full Name
histone deacetylase 2
NCBI Official Synonym Full Names
histone deacetylase 2
NCBI Official Symbol
HDAC2
NCBI Official Synonym Symbols
HD2; RPD3; YAF1
UniProt Protein Name
Histone deacetylase 2
UniProt Gene Name
HDAC2
UniProt Synonym Gene Names
HD2
NCBI Protein Information
histone deacetylase 2

NCBI Summary for HDAC2

This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
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Research Articles on HDAC2

1. Taken together, these data clearly show that FKBP3/Sp1/HDAC2/p27 control cell proliferation during non-small cell lung cancer development.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HDAC2 antibody

 Reference Product  PubMed Publications
 HDAC1 antibody  >376 publications with HDAC2 and HDAC1
 SP1 antibody  >35 publications with HDAC2 and SP1
 SIN3A antibody  >27 publications with HDAC2 and SIN3A
 DNMT1 antibody  >24 publications with HDAC2 and DNMT1
 MTA1 antibody  >22 publications with HDAC2 and MTA1
 DNMT3B antibody  >19 publications with HDAC2 and DNMT3B
 SP3 antibody  >18 publications with HDAC2 and SP3
 RELA antibody  >18 publications with HDAC2 and RELA
 YY1 antibody  >12 publications with HDAC2 and YY1
 SUV39H1 antibody  >12 publications with HDAC2 and SUV39H1

Pathways associated with anti-HDAC2 antibody

 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram

Diseases associated with anti-HDAC2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >186 publications with HDAC2 and Neoplasms
 Inflammation Antibodies  >91 publications with HDAC2 and Inflammation
 Pulmonary Disease, Chronic Obstructive Antibodies  >77 publications with HDAC2 and Pulmonary Disease, Chronic Obstructive
 Carcinoma Antibodies  >60 publications with HDAC2 and Carcinoma
 Adenocarcinoma Antibodies  >31 publications with HDAC2 and Adenocarcinoma
 Brain Diseases Antibodies  >29 publications with HDAC2 and Brain Diseases
 Necrosis Antibodies  >27 publications with HDAC2 and Necrosis
 Breast Neoplasms Antibodies  >23 publications with HDAC2 and Breast Neoplasms
 Leukemia, Myeloid Antibodies  >16 publications with HDAC2 and Leukemia, Myeloid
 Prostatic Neoplasms Antibodies  >15 publications with HDAC2 and Prostatic Neoplasms

Organs/Tissues associated with anti-HDAC2 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >110 publications with HDAC2 and Lung
 Brain Antibodies  >77 publications with HDAC2 and Brain
 Heart Antibodies  >72 publications with HDAC2 and Heart
 Blood Antibodies  >64 publications with HDAC2 and Blood
 Muscle Antibodies  >46 publications with HDAC2 and Muscle
 Nerve Antibodies  >27 publications with HDAC2 and Nerve
 Liver Antibodies  >26 publications with HDAC2 and Liver
 Vascular Antibodies  >25 publications with HDAC2 and Vascular
 Prostate Antibodies  >19 publications with HDAC2 and Prostate
 Embryonic Tissue Antibodies  >18 publications with HDAC2 and Embryonic Tissue
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