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N/H/K-RAS Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS477462

MBS477462 is an antibody targeting N/H/K-Ras. Also known as Anti-N/H/K-Ras Rabbit pAb. Reactive in Human, Mouse, Monkey. Host: Rabbit. More details

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Technical Datasheet View PDF
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Product Overview

Product Name
N/H/K-Ras, Polyclonal Antibody
Full Product Name
Anti-N/H/K-Ras Rabbit pAb
Product Gene Name
anti-N/H/K-Ras antibody
Product Synonym Gene Name
HRAS
Product Synonym Names
C-BAS/HAS; c-H-ras; C-HA-RAS1; CTLO; GTPase HRas; GTPase KRas; GTPase NRas; H-Ras-1; H-RASIDX; Ha-Ras; HAMSV; HRAS; HRAS1; K RAS2A; K RAS2B; K RAS4A; K RAS4B; K-RAS; KRAS; KRAS1; KRAS2; N-RAS; N-terminally processed; NRAS; NRAS1; p21ras; RASH_HUMAN; RASH1; RASK2; Transforming protein p21; v Ha ras Harvey rat sarcoma viral oncogene homolog; v Ki ras2 Kirsten rat sarcoma viral oncogene homolog; v ras neuroblastoma RAS viral oncogene homolog
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Monkey
Form/Format
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purity/Purification
Affinity Purified
Molecular Weight
21kDa
OMIM
137550
3D Structure
ModBase 3D Structure for P01111
Immunogen
Synthesized peptide derived from N/H/K-Ras. at AA range: 10-90.
Subcellular Location
Golgi apparatus membrane; Lipid-anchor
Applications Tested/Suitable for anti-N/H/K-Ras antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-N/H/K-Ras antibody
WB: 1:500-1:2000
IHC: 1:100-1:300

Western Blot (WB) of anti-N/H/K-Ras antibody

Western blot detection of N/H/K-Ras in T47D, 3T3, COS7 and Hela cell lysates using N/H/K-Ras rabbit pAb (1:1000 diluted).Predicted band size:17kDa.Observed band size:17kDa.
Rabbit Anti-N/H/K-RAS Polyclonal Antibody – Cat# MBS477462

Other Notes

Small volumes of anti-N/H/K-Ras antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for N/H/K-Ras. It may not necessarily be applicable to this product.

NCBI GI #
4505451
NCBI GeneID
4893
NCBI Accession #
NP_002515.1
UniProt Primary Accession #
P01111
UniProt Secondary Accession #
Q14971; Q15104; Q15282
UniProt Related Accession #
P01111
GenBank Nucleotide #
NM_002524.4
NCBI Official Full Name
GTPase NRas
NCBI Official Synonym Full Names
NRAS proto-oncogene, GTPase
NCBI Official Symbol
NRAS
NCBI Official Synonym Symbols
NS6; CMNS; NCMS; ALPS4; N-ras; NRAS1
UniProt Protein Name
GTPase NRas
UniProt Synonym Protein Names
Transforming protein N-Ras
Protein Family
Negative RAS protein regulator protein
UniProt Gene Name
NRAS
UniProt Synonym Gene Names
HRAS1
NCBI Protein Information
GTPase NRas

NCBI Summary for N/H/K-Ras

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
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UniProt Comments for N/H/K-Ras

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Research Articles on N/H/K-Ras

1. NRAS-mutant tumors tended to behave more aggressively particularly in early stages of the disease in studied high-risk melanoma population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-N/H/K-Ras antibody

 Reference Product  PubMed Publications
 BRAF antibody  >441 publications with N/H/K-Ras and BRAF
 KIT antibody  >111 publications with N/H/K-Ras and KIT
 PIK3CA antibody  >99 publications with N/H/K-Ras and PIK3CA
 EGFR antibody  >76 publications with N/H/K-Ras and EGFR
 RAF1 antibody  >25 publications with N/H/K-Ras and RAF1
 ERBB2 antibody  >19 publications with N/H/K-Ras and ERBB2
 SOS1 antibody  >17 publications with N/H/K-Ras and SOS1
 FOS antibody  >3 publications with N/H/K-Ras and FOS

Pathways associated with anti-N/H/K-Ras antibody

 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activation Of RAS In B Cells Pathway antibodies  Activation Of RAS In B Cells Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram

Diseases associated with anti-N/H/K-Ras antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >613 publications with N/H/K-Ras and Neoplasms
 Melanoma Antibodies  >316 publications with N/H/K-Ras and Melanoma
 Carcinoma Antibodies  >105 publications with N/H/K-Ras and Carcinoma
 Hematologic Diseases Antibodies  >89 publications with N/H/K-Ras and Hematologic Diseases
 Colorectal Neoplasms Antibodies  >50 publications with N/H/K-Ras and Colorectal Neoplasms
 Cell Transformation, Neoplastic Antibodies  >46 publications with N/H/K-Ras and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >42 publications with N/H/K-Ras and Neoplasms, Experimental
 Thyroid Diseases Antibodies  >41 publications with N/H/K-Ras and Thyroid Diseases
 Lymphoma Antibodies  >38 publications with N/H/K-Ras and Lymphoma
 Lung Neoplasms Antibodies  >35 publications with N/H/K-Ras and Lung Neoplasms

Organs/Tissues associated with anti-N/H/K-Ras antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >186 publications with N/H/K-Ras and Skin
 Blood Antibodies  >113 publications with N/H/K-Ras and Blood
 Bone Antibodies  >61 publications with N/H/K-Ras and Bone
 Bone Marrow Antibodies  >52 publications with N/H/K-Ras and Bone Marrow
 Lung Antibodies  >51 publications with N/H/K-Ras and Lung
 Lymph Node Antibodies  >31 publications with N/H/K-Ras and Lymph Node
 Lymph Antibodies  >30 publications with N/H/K-Ras and Lymph
 Brain Antibodies  >25 publications with N/H/K-Ras and Brain
 Liver Antibodies  >23 publications with N/H/K-Ras and Liver
 Nerve Antibodies  >17 publications with N/H/K-Ras and Nerve
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