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IL-6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS477486

MBS477486 is an antibody targeting IL-6. Also known as Anti-IL-6 Rabbit pAb. Reactive in Human, Monkey. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
IL-6, Polyclonal Antibody
Full Product Name
Anti-IL-6 Rabbit pAb
Product Gene Name
Product Synonym Gene Name
IL6; SUGP2; KIAA0365; SFRS14
Product Synonym Names
Interleukin BSF 2; B cell differentiation factor; B cell stimulatory factor 2; B-cell stimulatory factor 2; BSF 2; BSF-2; BSF2; CDF; CTL differentiation factor; Hepatocyte stimulatory factor; HGF; HSF; Hybridoma growth factor; Hybridoma growth factor Interferon beta-2; IFN-beta-2; IFNB2; IL 6; IL-6; IL6; IL6_HUMAN; Interferon beta 2; Interferon beta-2; Interleukin 6; Interleukin 6 (interferon beta 2); Interleukin BSF 2; Interleukin-6
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Monkey
Form/Format
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purity/Purification
Affinity Purified
Molecular Weight
23kDa
OMIM
147620
3D Structure
ModBase 3D Structure for P05231
Immunogen
Synthesized peptide derived from IL-6. at AA range: INTERNAL.
Subcellular Location
Secreted
Applications Tested/Suitable for anti-IL-6 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC) Paraffin
Application Notes for anti-IL-6 antibody
WB: 1:500-1:2000
IHC-p: 1:100-1:300
ELISA: 1:20000

Western Blot (WB) of anti-IL-6 antibody

Western blot detection of IL-6 in T47D, COS7 and Hela cell lysates using IL-6 rabbit pAb (1:3000 diluted).Predicted band size:23kDa.Observed band size:23kDa.
Rabbit Anti-IL-6 Polyclonal Antibody – Cat# MBS477486

Western Blot (WB) of anti-IL-6 antibody

Western Blot analysis of K562 cells using IL-6 Polyclonal Antibody.
Rabbit Anti-IL-6 Polyclonal Antibody, Western Blot (WB) – Cat# MBS477486

Immunohistochemistry (IHC) of anti-IL-6 antibody

Immunohistochemical analysis of paraffin-embedded human-lung, antibody was diluted at 1:100
Rabbit Anti-IL-6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS477486

Immunohistochemistry (IHC) of anti-IL-6 antibody

Immunohistochemical analysis of paraffin-embedded human-lung, antibody was diluted at 1:100
Rabbit Anti-IL-6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS477486

Other Notes

Small volumes of anti-IL-6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-6. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
interleukin-6 isoform 1
NCBI Official Synonym Full Names
interleukin 6
NCBI Official Symbol
IL6
NCBI Official Synonym Symbols
CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2
UniProt Protein Name
Interleukin-6
UniProt Synonym Protein Names
B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2
UniProt Gene Name
IL6
UniProt Synonym Gene Names
IFNB2; IL-6; BSF-2; CDF; IFN-beta-2
NCBI Protein Information
interleukin-6

NCBI Summary for IL-6

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
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UniProt Comments for IL-6

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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