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Caveolin-2 (CAV2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS477736

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae… More details

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Product Overview

Product Name
Caveolin-2 (CAV2), Polyclonal Antibody
Full Product Name
Anti-Caveolin-2 Rabbit pAb
Product Gene Name
anti-CAV2 antibody
Product Synonym Names
Caveolae protein 20 Kd; Caveolin 2; Caveolin 2 isoform a and b; Caveolin-2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity Chromatography
Specificity
Caveolin-2 Antibody detects endogenous levels of total Caveolin-2
Preparation and Storage
Store at 4 degree C for short term.
Store at-20 degree C for long term.
Avoid freeze/thaw cycle.
Molecular Weight
18kDa
OMIM
601048
3D Structure
ModBase 3D Structure for P51636
Immunogen
A synthesized peptide derived from human Caveolin-2
Subcellular Location
Membrane; Caveola; Peripheral membrane protein
Applications Tested/Suitable for anti-CAV2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP)
Application Notes for anti-CAV2 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
ICC/IF: 1:50-1:200
IP: 1:50

Western Blot (WB) of anti-CAV2 antibody

Western blot analysis of Caveolin 2 expression in HeLa cell lysate.
Rabbit Anti-CAV2 Polyclonal Antibody – Cat# MBS477736

Immunohistochemistry (IHC) of anti-CAV2 antibody

Immunohistochemical analysis of paraffin-embedded human colon, using Caveolin-2 Antibody.
Rabbit Anti-CAV2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS477736

Other Notes

Small volumes of anti-CAV2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CAV2 purchase

MBS477736 is an antibody targeting CAV2. Also known as Anti-Caveolin-2 Rabbit pAb. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CAV2. It may not necessarily be applicable to this product.

NCBI GI #
332164664
NCBI GeneID
858
NCBI Accession #
NP_001193676.1
UniProt Primary Accession #
P51636
UniProt Secondary Accession #
Q9UGM7; A4D0U2
UniProt Related Accession #
P51636
GenBank Nucleotide #
NM_001206747.1
NCBI Official Full Name
caveolin-2 isoform b
NCBI Official Synonym Full Names
caveolin 2
NCBI Official Symbol
CAV2
NCBI Official Synonym Symbols
CAV
UniProt Protein Name
Caveolin-2
Protein Family
Caveolin
UniProt Gene Name
CAV2
NCBI Protein Information
caveolin-2

NCBI Summary for CAV2

The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]
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UniProt Comments for CAV2

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression ().
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Research Articles on CAV2

1. this study confirmed the association of rs4236601 with primary open-angle glaucoma in different Chinese cohorts, and also found a common single-nucleotide polymorphism rs3801994 of diverse associations with primary open-angle glaucoma between Chinese and Japanese

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CAV2 antibody

 Reference Product  PubMed Publications
 CAV1 antibody  >110 publications with CAV2 and CAV1
 SRC antibody  >7 publications with CAV2 and SRC
 MALL antibody  >1 publications with CAV2 and MALL
 EGFR antibody  >1 publications with CAV2 and EGFR

Pathways associated with anti-CAV2 antibody

 Products by Pathway  Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Integrin-mediated Cell Adhesion Pathway antibodies  Integrin-mediated Cell Adhesion Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram

Diseases associated with anti-CAV2 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >43 publications with CAV2 and Brain Diseases
 Neoplasms Antibodies  >31 publications with CAV2 and Neoplasms
 Inflammation Antibodies  >11 publications with CAV2 and Inflammation
 Glaucoma, Open-Angle Antibodies  >6 publications with CAV2 and Glaucoma, Open-Angle
 Lung Neoplasms Antibodies  >5 publications with CAV2 and Lung Neoplasms
 Drug Toxicity Antibodies  >4 publications with CAV2 and Drug Toxicity
 Necrosis Antibodies  >3 publications with CAV2 and Necrosis
 Prostatic Neoplasms Antibodies  >3 publications with CAV2 and Prostatic Neoplasms
 Fibrosis Antibodies  >2 publications with CAV2 and Fibrosis
 Kidney Diseases Antibodies  >2 publications with CAV2 and Kidney Diseases

Organs/Tissues associated with anti-CAV2 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >26 publications with CAV2 and Kidney
 Lung Antibodies  >18 publications with CAV2 and Lung
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