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Heme Oxygenase 1 (HMOX1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS477820

Hemeoxygenase (HO) is the rate-limiting enzyme in the catabolism of heme that results in the release of carbon monoxide, iron, and biliverdin. The products of this enzymatic reaction play important biological roles in antioxidant, anti-inflammatory and… More details

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Product Overview

Product Name
Heme Oxygenase 1 (HMOX1), Polyclonal Antibody
Full Product Name
Anti-Heme Oxygenase 1 Rabbit pAb
Product Gene Name
Product Synonym Names
HO-1; HSP32
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity Chromatography
Specificity
Heme Oxygenase 1 Antibody detects endogenous levels of total Heme Oxygenase 1
Preparation and Storage
Store at 4 degree C for short term.
Store at-20 degree C for long term.
Avoid freeze/thaw cycle.
Molecular Weight
32kDa
OMIM
141250
3D Structure
ModBase 3D Structure for P09601
Immunogen
A synthesized peptide derived from human Heme Oxygenase 1
Subcellular Location
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side
Applications Tested/Suitable for anti-HMOX1 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
Application Notes for anti-HMOX1 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
IP: 1:50
FC/FACS: 1:50

Western Blot (WB) of anti-HMOX1 antibody

Western blot analysis of Heme Oxygenase 1 in mouse spleen lysate.
Rabbit Anti-HMOX1 Polyclonal Antibody – Cat# MBS477820

Immunohistochemistry (IHC) of anti-HMOX1 antibody

Immunohistochemical analysis of paraffin-embedded human liver, using Heme Oxygenase 1 Antibody.
Rabbit Anti-HMOX1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS477820

Other Notes

Small volumes of anti-HMOX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HMOX1 purchase

MBS477820 is an antibody targeting HMOX1. Also known as Anti-Heme Oxygenase 1 Rabbit pAb. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HMOX1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
heme oxygenase 1
NCBI Official Synonym Full Names
heme oxygenase 1
NCBI Official Symbol
HMOX1
NCBI Official Synonym Symbols
HO-1; HSP32; HMOX1D; bK286B10
UniProt Protein Name
Heme oxygenase 1
Protein Family
UniProt Gene Name
HMOX1
UniProt Synonym Gene Names
HO; HO1; HO-1
NCBI Protein Information
heme oxygenase 1

NCBI Summary for HMOX1

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]
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UniProt Comments for HMOX1

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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