Prostacyclin (PTGIS) Antibody – Monoclonal

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]

PTGIS: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2). Belongs to the cytochrome P450 family.

Protein type: Lipid Metabolism - arachidonic acid; Membrane protein, integral; Isomerase; EC 5.3.99.4; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 20q13.13

Cellular Component: extracellular space; endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; caveola; nucleus

Molecular Function: protein binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; iron ion binding; heme binding; prostaglandin-I synthase activity; monooxygenase activity

Biological Process: positive regulation of angiogenesis; vitamin metabolic process; NAD metabolic process; inhibition of NF-kappaB transcription factor; nicotinamide metabolic process; negative regulation of nitric oxide biosynthetic process; negative regulation of inflammatory response; xenobiotic metabolic process; cyclooxygenase pathway; icosanoid metabolic process; arachidonic acid metabolic process; prostaglandin biosynthetic process; water-soluble vitamin metabolic process

Disease: Hypertension, Essential