PKC-beta II Protein

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

PKCB: an AGC kinase of the PKC family. A classical PKC downstream of many mitogenic receptors. Activates the NF-kappaB signaling pathway in B cells after antigen-receptor signaling. Two splice-variant isoforms have been described.

Protein type: Motility/polarity/chemotaxis; EC 2.7.11.13; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, AGC; AGC group; PKC family; Alpha subfamily

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: nucleoplasm; membrane; cytoplasm; plasma membrane; nucleus; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; protein kinase C activity; androgen receptor binding; protein kinase C binding; ligand-dependent nuclear receptor transcription coactivator activity; histone binding; zinc ion binding; calcium channel regulator activity; chromatin binding; ATP binding

Biological Process: platelet activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; B cell activation; apoptosis; positive regulation of B cell receptor signaling pathway; mitotic nuclear envelope disassembly; negative regulation of insulin receptor signaling pathway; signal transduction; protein amino acid phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; activation of NF-kappaB transcription factor; cellular calcium ion homeostasis; regulation of transcription from RNA polymerase II promoter; synaptic transmission; B cell receptor signaling pathway; positive regulation of angiogenesis; lipoprotein transport; calcium ion transport; response to hypoxia; mitotic cell cycle; blood coagulation; vascular endothelial growth factor receptor signaling pathway