Isoleucyl Trna Synthetase (IARS) Antibody – Rabbit Polyclonal

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]

IARS: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Two alternatively spliced variants have been isolated that represent alternate 5' UTRs. [provided by RefSeq, Jul 2008]

Protein type: Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Aminoacyl-tRNA synthetase; EC 6.1.1.5; Ligase; Translation; Translation regulation

Chromosomal Location of Human Ortholog: 9q22.31

Cellular Component: aminoacyl-tRNA synthetase multienzyme complex; cytoplasm; cytosol; extracellular exosome; membrane

Molecular Function: ATP binding; GTPase binding; isoleucine-tRNA ligase activity; ligase activity; protein binding; tRNA binding

Biological Process: isoleucyl-tRNA aminoacylation; osteoblast differentiation; regulation of translational fidelity; tRNA aminoacylation for protein translation

Disease: Growth Retardation, Intellectual Developmental Disorder, Hypotonia, And Hepatopathy