Glysyl-Trna Synthetase (GRS) Antibody – Mouse Monoclonal

Glycyl-tRNA synthetase catalyzes the ligation of glycine with glycyl-tRNA using ATP and its mutation induces Charcot-Marie-Tooth (CMT) disease.

1. Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis. Min Chul Park et al., PNAS, Vol.109, E640-E647, 2012. 2. Internally Deleted Human tRNA Synthetase Suggests Evolutionary Pressure for Repurposing. Zhiwen Xu et al., Structure, Vol.20, 1470-1477, 2012. 3. Aminoacyl tRNA synthetases and their connections to disease. Sang Gyu Park et al., PNAS, Vol.105(32),11043-11049, 2008. 4. Functional Analyses of Glycyl-tRNA Synthetase Mutations Suggest a Key Role for tRNA-Charging Enzymes in Peripheral Axons. Anthony Antonellis et al., The Journal of Neuroscience, Vol.26(41), 10397-10406, 2006. 5. Severe childhood SMA and axonal CMT due to anticodon binding domain mutations in the GARS gene. James P.A. et al., Neurology, Vol.67, 1710-1712, 2006. 6. Phenotypic spectrum of disorders associated with glycyl-tRNA synthetase mutations. Kumaraswamy Sivakumar et al., Brain, Vol.128, 2304-2314, 2005. 7. Glycyl tRNA synthetase mutations in Charcot-MarieTooth disease type 2D and distal spinal muscular atrophy type V. Am. Antonellis A., et al., J. Hum. Genet., Vol.72, 1293-1299, 2003.

Small volumes of anti-GRS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS490313 is an antibody targeting GRS. Also known as Glysyl-tRNA Synthetase (GRS). Reactive in Human, Mouse
Other species are not tested.. Host: Mouse.