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Lysyl-Trna Synthetase (KRS) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS490314

Lysyl-tRNA synthetase(KRS) is a component of multi-ARS complex and catalyzes the ligation of lysine with lysyl-tRNA KRS is secreted from cancer cell by TNF-alpha and activates. More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
Lysyl-tRNA Synthetase (KRS), Monoclonal Antibody
Full Product Name
Lysyl-tRNA Synthetase (KRS)
Product Gene Name
anti-KRS antibody
Product Synonym Names
Lysyl-tRNA Synthetase mAb; KARS; LysylRS
Clonality
Monoclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human, Mouse
Other species are not tested.
Form/Format
Containing 0.05% sodium azide for preservative.
Preparation and Storage
Store at 4 degree C or -20 degree C.
Immunogen
Full length native human recombinant KRS.
Applications Tested/Suitable for anti-KRS antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-KRS antibody
WB: 1:1000
IHC: 1:5000

Western Blot (WB) of anti-KRS antibody

Mouse Anti-KRS Monoclonal Antibody – Cat# MBS490314

Immunohistochemistry (IHC) of anti-KRS antibody

Mouse Anti-KRS Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS490314

Product References and Citations for anti-KRS antibody

1. Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction. Dae Gyu Kim et al., NATURE CHEMICAL BIOLOGY, 10 November, 2013. 2. Structural Switch of Lysyl-tRNA Synthetase between Translation and Transcription. Yifat Ofir-Birin et al., Molecular Cell, Vol.49, 1-13, 2013. 3. Entamoeba lysyl-tRNA Synthetase Contains a Cytokine-Like Domain with Chemokine Activity towards Human Endothelial Cells. Manuel Castro de Moura et al., PLOS NEGLECTED TROPICAL DISEASES, Vol.5, Issue 11, e1398, 2011. 4. Human lysyl-tRNA synthetase is secreted to trigger pro-inflammatory response. Sanggyu Park et al., Proc. Natl. Acad. Sci., Vol.102, 6356-6361, 2005. 5. Cellular Distribution of lysyl-tRNA Synthetase and Its Interaction with Gag during Human Immunodeficiency Virus Type 1 Assembly. Rabih Halwani et al., JOURNAL OF VIROLOGY, Vol.78, 7553-7564, 2004.

Other Notes

Small volumes of anti-KRS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KRS purchase

MBS490314 is an antibody targeting KRS. Also known as Lysyl-tRNA Synthetase (KRS). Reactive in Human, Mouse
Other species are not tested.. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for KRS. It may not necessarily be applicable to this product.

NCBI GI #
2366752
NCBI GeneID
3735
NCBI Accession #
BAA22084.1
UniProt Related Accession #
Q15046
NCBI Official Full Name
Lysyl tRNA Synthetase
NCBI Official Synonym Full Names
lysyl-tRNA synthetase
NCBI Official Symbol
KARS
NCBI Official Synonym Symbols
KRS; KARS1; KARS2; CMTRIB; DFNB89
NCBI Protein Information
lysine--tRNA ligase

NCBI Summary for KRS

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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Research Articles on KRS

1. This study demonstrates that human mitochondrial AspRS, ArgRS, and LysRS, each have a specific sub-mitochondrial distribution, with ArgRS being exclusively localized in the membrane, LysRS exclusively in the soluble fraction, and AspRS being present in both.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KRS antibody

 Reference Product  PubMed Publications
 AARS antibody  >3 publications with KRS and AARS
 MARS antibody  >2 publications with KRS and MARS
 RARS antibody  >2 publications with KRS and RARS
 LARS antibody  >2 publications with KRS and LARS
 EPRS antibody  >2 publications with KRS and EPRS
 DARS antibody  >1 publications with KRS and DARS
 IARS antibody  >1 publications with KRS and IARS
 AIMP1 antibody  >1 publications with KRS and AIMP1
 AIMP2 antibody  >1 publications with KRS and AIMP2

Pathways associated with anti-KRS antibody

 Products by Pathway  Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Cytosolic TRNA Aminoacylation Pathway antibodies  Cytosolic TRNA Aminoacylation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Mitochondrial TRNA Aminoacylation Pathway antibodies  Mitochondrial TRNA Aminoacylation Pathway Diagram
 TRNA Aminoacylation Pathway antibodies  TRNA Aminoacylation Pathway Diagram

Diseases associated with anti-KRS antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >80 publications with KRS and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >60 publications with KRS and Cardiovascular Diseases
 Bone Diseases Antibodies  >20 publications with KRS and Bone Diseases
 Inflammation Antibodies  >19 publications with KRS and Inflammation
 Necrosis Antibodies  >17 publications with KRS and Necrosis
 Kidney Diseases Antibodies  >15 publications with KRS and Kidney Diseases
 Hyperplasia Antibodies  >14 publications with KRS and Hyperplasia
 Adenocarcinoma Antibodies  >12 publications with KRS and Adenocarcinoma
 Liver Neoplasms Antibodies  >8 publications with KRS and Liver Neoplasms
 Anemia Antibodies  >8 publications with KRS and Anemia

Organs/Tissues associated with anti-KRS antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >160 publications with KRS and Blood
 Brain Antibodies  >146 publications with KRS and Brain
 Vascular Antibodies  >44 publications with KRS and Vascular
 Liver Antibodies  >42 publications with KRS and Liver
 Lung Antibodies  >39 publications with KRS and Lung
 Bone Antibodies  >37 publications with KRS and Bone
 Heart Antibodies  >36 publications with KRS and Heart
 Nerve Antibodies  >34 publications with KRS and Nerve
 Kidney Antibodies  >27 publications with KRS and Kidney
 Eye Antibodies  >26 publications with KRS and Eye
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