TRS (Threonyl-Trna Synthetase) (TRS) Recombinant Protein

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase.

1. Yeast mitochondrial threonyl-tRNA synthetase recognizes tRNA isoacceptors by distinct mechanisms and promotes CUN codon reassignment. Jiqiang Ling et al., PNAS Early Edition, 3281-3286, 2012. 2. Dual targeting of aminoacyl-tRNA synthetases to the apicoplast and cytosol in Plasmodium falciparum. Katherine E. Jackson et al., International Journal for Parasitology, Vol.42, 177-186, 2012. 3. Post-transfer editing mechanism of a D-aminoacyltRNA deacylase-like domain in threonyl-tRNA synthetase from archaea. Hussain T et al., EMBO J., Vol.25, 4152-4162, 2006. 4. Unusually high frequency of autoantibodies to PL-7 associated with milder muscle disease in Japanese patients with polymyositis/dermatomyositis. Yamasaki Y. et al., Arthritis Rheum., Vol.54, 2004-2009, 2006. 5. A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases. Ruan B. et al., J. Biol. Chem., Vol.280, 571-577, 2004. 6. Threonyl-tRNA synthetase of archaea: importance of the discriminator base in the aminoacylation of threonine tRNA. Ishikura H. et al., Nucleic Acids Symp. Ser., Vol.44, 83-84, 2000. 7. Conformational movements and cooperativity upon amino acid, ATP and tRNA binding in threonyl-tRNA synthetase. Torres-Larios A. et al., J. Mol. Biol., Vol.331, 201-211, 2003.

Small volumes of TRS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS490324 is a recombinant protein targeting TRS. Also known as TRS (Threonyl-tRNA Synthetase). Host: E Coli.