Arachidonate Lipoxygenase 3 (ALOXE3) ELISA Kit for Goat

Name: Goat ALOXE3 ELISA Kit; Arachidonate Lipoxygenase 3; MyBioSource
Brand: MyBioSource
SKU: MBS049033
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS049033

MBS049033 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Arachidonate Lipoxygenase 3 (ALOXE3) ELISA Kit target analytes in biological samples. The concentration gradients of the… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Arachidonate Lipoxygenase 3 (ALOXE3), ELISA Kit

Full Product Name

Goat Arachidonate Lipoxygenase 3 ELISA Kit

Product Gene Name

ALOXE3 elisa kit

Species Reactivity

Goat

Preparation and Storage

Store all reagents at 2-8 degree C

Molecular Weight

77,983 Da

OMIM

152390

3D Structure

ModBase 3D Structure for P09917

Other Notes

Small volumes of ALOXE3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ALOXE3. It may not necessarily be applicable to this product.

NCBI GI #

371877598

NCBI GeneID

240

NCBI Accession #

NP_001243083.1

UniProt Primary Accession #

P09917

UniProt Secondary Accession #

Q5JQ14; B7ZLS0; E5FPY5; E5FPY7; E5FPY8

UniProt Related Accession #

P09917

GenBank Nucleotide #

NM_001256154.1

NCBI Official Full Name

arachidonate 5-lipoxygenase isoform 3

NCBI Official Synonym Full Names

arachidonate 5-lipoxygenase

NCBI Official Symbol

ALOX5

NCBI Official Synonym Symbols

5-LO; 5LPG; LOG5; 5-LOX

UniProt Protein Name

Arachidonate 5-lipoxygenase

Protein Family

Hydroperoxide isomerase

UniProt Gene Name

ALOX5

UniProt Synonym Gene Names

LOG5; 5-LO

UniProt Entry Name

LOX5_HUMAN

NCBI Protein Information

arachidonate 5-lipoxygenase; LOX-5; leukotriene A4 synthase; arachidonic acid 5-lipoxygenase; arachidonic 5-lipoxygenase alpha-10 isoform; arachidonic 5-lipoxygenase delta-13 isoform; arachidonic 5-lipoxygenase delta-p10 isoform; arachidonic 5-lipoxygenase delta-10-13 isoform

NCBI Summary for ALOXE3

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

UniProt Comments for ALOXE3

5-LO: arachidonate 5-lipoxygenase. Arachidonic acid promotes its phosphorylation by p38 MAPK-regulated MAPKAP kinases. Upregulated in glioblastoma multiforme and colon, pancreatic and bladder cancer.

Protein type: Oxidoreductase; Lipid Metabolism - linoleic acid; Nuclear envelope; Lipid Metabolism - arachidonic acid; EC 1.13.11.34

Chromosomal Location of Human Ortholog: 10q11.2

Cellular Component: extracellular space; nuclear membrane; nuclear matrix; nuclear envelope lumen; nuclear envelope; cytosol

Molecular Function: protein binding; iron ion binding; arachidonate 5-lipoxygenase activity

Biological Process: leukotriene biosynthetic process; leukotriene production during acute inflammatory response; lipoxygenase pathway; arachidonic acid metabolic process; leukotriene metabolic process

Disease: Asthma, Susceptibility To

Research Articles on ALOXE3

1. 5-LO disruption improves wound healing and alters fibroblast function by an antioxidant mechanism based on HO-1 induction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ALOXE3 elisa kit

Reference Product	PubMed Publications
PTGS2 elisa kit	>272 publications with ALOXE3 and PTGS2
ALOX5AP elisa kit	>201 publications with ALOXE3 and ALOX5AP
PTGS1 elisa kit	>107 publications with ALOXE3 and PTGS1
PLA2G4A elisa kit	>60 publications with ALOXE3 and PLA2G4A
LTA4H elisa kit	>29 publications with ALOXE3 and LTA4H
LTC4S elisa kit	>27 publications with ALOXE3 and LTC4S
COTL1 elisa kit	>9 publications with ALOXE3 and COTL1
MAPKAPK2 elisa kit	>8 publications with ALOXE3 and MAPKAPK2

Pathways associated with ALOXE3 elisa kit

Products by Pathway	Pathway Diagram
Arachidonic Acid Metabolism Pathway antibodies	Arachidonic Acid Metabolism Pathway Diagram
Arachidonic Acid Metabolism Pathway antibodies	Arachidonic Acid Metabolism Pathway Diagram
Arachidonic Acid Metabolism Pathway antibodies	Arachidonic Acid Metabolism Pathway Diagram
Eicosanoid Synthesis Pathway antibodies	Eicosanoid Synthesis Pathway Diagram
IL-5 Signaling Pathway antibodies	IL-5 Signaling Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
Ovarian Steroidogenesis Pathway antibodies	Ovarian Steroidogenesis Pathway Diagram
Ovarian Steroidogenesis Pathway antibodies	Ovarian Steroidogenesis Pathway Diagram
Selenium Pathway antibodies	Selenium Pathway Diagram

Diseases associated with ALOXE3 elisa kit

Disease Name	Pubmed Publications
Inflammation Antibodies	>580 publications with ALOXE3 and Inflammation
Neoplasms Antibodies	>325 publications with ALOXE3 and Neoplasms
Asthma Antibodies	>249 publications with ALOXE3 and Asthma
Lung Diseases Antibodies	>237 publications with ALOXE3 and Lung Diseases
Atherosclerosis Antibodies	>122 publications with ALOXE3 and Atherosclerosis
Necrosis Antibodies	>115 publications with ALOXE3 and Necrosis
Edema Antibodies	>94 publications with ALOXE3 and Edema
Heart Diseases Antibodies	>59 publications with ALOXE3 and Heart Diseases
Neoplasms, Experimental Antibodies	>52 publications with ALOXE3 and Neoplasms, Experimental
Pain Antibodies	>49 publications with ALOXE3 and Pain

Organs/Tissues associated with ALOXE3 elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1137 publications with ALOXE3 and Blood
Lung Antibodies	>258 publications with ALOXE3 and Lung
Brain Antibodies	>131 publications with ALOXE3 and Brain
Muscle Antibodies	>118 publications with ALOXE3 and Muscle
Bone Antibodies	>81 publications with ALOXE3 and Bone
Heart Antibodies	>72 publications with ALOXE3 and Heart
Kidney Antibodies	>66 publications with ALOXE3 and Kidney
Bone Marrow Antibodies	>59 publications with ALOXE3 and Bone Marrow
Intestine Antibodies	>51 publications with ALOXE3 and Intestine
Prostate Antibodies	>39 publications with ALOXE3 and Prostate