Rf-Absorbent Kit

Principle of the Assay: Rheumatoid factors are autoantibodies (anti-IgG) mainly of the IgM class. They can be detected in serum of approx. 5 % of healthy individuals. IgM rheumatoid factors preferably bind to IgG immune complexes; therefore, false positive results may appear in the pathogen-specific IgM detection. Furthermore, it is possible that weak-binding pathogen-specific IgM antibodies are displaced by stronger-binding IgG antibodies. In this case, IgM-detection can bring about false negative results. This Rf-Absorbent precipitates up to 15 mg IgG/ml (undiluted serum). The IgM rheumatoid factor binds to the precipitate. Consequently, the IgG antibodies as well as the IgM rheumatoid factors are not reactive in the immunoassay. The use of this Rf-Absorbent can minimize false positive as well as false negative results.

Small volumes of Rf-Absorbent kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS495201 is a kit targeting Rf-Absorbent.