Sex Determining Region Y Box Protein 6 (SOX6) ELISA Kit for Duck

This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

SOX6: Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 11p15.3

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; transcription factor activity

Biological Process: muscle development; erythrocyte development; transcription, DNA-dependent; in utero embryonic development; cell morphogenesis; negative regulation of transcription from RNA polymerase II promoter; gene silencing; oligodendrocyte cell fate specification; cardiac muscle cell differentiation; post-embryonic development; positive regulation of chondrocyte differentiation; regulation of transcription, DNA-dependent; astrocyte differentiation; cartilage development; positive regulation of transcription from RNA polymerase II promoter