Retinoid X Receptor, B-Isotype (RXRB) Antibody – Mouse Monoclonal

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5

By similarity. Specifically binds 9-cis retinoic acid (9C-RA).

Subunit structure: Homodimer

By similarity. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Ref.1

Subcellular location: Nucleus.

Tissue specificity: Expressed in a variety of tumor cell lines. Ref.10

Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similarities: Belongs to the nuclear hormone receptor family. NR2 subfamily.Contains 1 nuclear receptor DNA-binding domain.

Sequence caution: The sequence BAD92481.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.