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Visinin-Like Protein 1 (VSNL1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS500046

MBS500046 is an antibody targeting VSNL1. Also known as Anti-Visinin-Like Protein 1 (VSNL1). Reactive in Bovine, human, mouse, rat. Host: Mouse. Mouse monoclonal antibody More details

$495 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Visinin-Like Protein 1 (VSNL1), Monoclonal Antibody
Full Product Name
Anti-Visinin-Like Protein 1 (VSNL1)
Product Gene Name
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2D11
Host
Mouse
Species Reactivity
Bovine, human, mouse, rat
Form/Format
100 ul liquid containing 10 mM sodium azide.
Purity/Purification
Affinity Purified (Affinity purified from tissue culture supernatant.)
Specificity
Specific for the ~22k protein
Preparation and Storage
Store at -20 degree C in undiluted aliquots; stable for at least 1 year. Avoid freeze/thaw cycles.
Molecular Weight
22
Chromosome Location
Chromosome: 2; NC_000002.12 (17540540..17656439). Location: 2p24.3
OMIM
600817
3D Structure
ModBase 3D Structure for P62760
Antigen
Recombinant full length human VSNL1 expressed in and purified from E. Coli.
Immunogen Information
Recombinant human VSNL1 purified from E. coli
Immunogen Species
Human
Species Reactivity Note
The antibody has been directly tested for reactivity in bovine, human, mouse and rat.
Biological Significance
Visinin-like protein 1 (VSNL1), also known as VILIP1, is a calcium sensor protein expressed exclusively in neurons. Highest levels of VSNL1 expression are found in cerebellar Purkinje cells. VSNL1 has been implicated in the modulation of cell signaling cascades via regulation of adenyl cyclase activity (Braunewell et al., 1997). Additionally, VSNL1 has been associated with amyloid plaques and neurofibrillar tangles in Alzheimer's disease (Schnurra et al., 2001).
Applications Tested/Suitable for anti-VSNL1 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-VSNL1 antibody
Quality Control: Western blots performed on each lot.
WB: 1:2,000
IF: 1: 500

Testing Data of anti-VSNL1 antibody

Mouse Anti-VSNL1 Monoclonal Antibody – Cat# MBS500046

Product References and Citations for anti-VSNL1 antibody

• Braunewell KH, Spilker C, Behnisch T, Gundelfinger ED (1997) The neuronal calcium-sensor protein VILIP modulates cyclic AMP accumulation in stably transfected C6 glioma cells: amino-terminal myristoylation determines functional activity. J. Neurochem. 68 (5): 2129-39.
• Schnurra I, Bernstein HG, Riederer P, Braunewell KH (2002) The neuronal calcium sensor protein VILIP-1 is associated with amyloid plaques and extracellular tangles in Alzheimer's disease and promotes cell death and tau phosphorylation in vitro: a link between calcium sensors and Alzheimer's disease. Neurobiol. Dis. 8 (5): 900-9.

Other Notes

Small volumes of anti-VSNL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for VSNL1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
visinin-like protein 1
NCBI Official Synonym Full Names
visinin-like 1
NCBI Official Symbol
VSNL1
NCBI Official Synonym Symbols
HLP3; VILIP; HPCAL3; HUVISL1; VILIP-1
UniProt Protein Name
Visinin-like protein 1
UniProt Synonym Protein Names
Hippocalcin-like protein 3
Protein Family
UniProt Gene Name
VSNL1
UniProt Synonym Gene Names
VISL1; VILIP; VLP-1; HLP3
UniProt Entry Name
VISL1_HUMAN
NCBI Protein Information
visinin-like protein 1; VLP-1; hippocalcin-like protein 3

NCBI Summary for VSNL1

This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
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UniProt Comments for VSNL1

Function: Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner

By similarity.

Tissue specificity: Brain and retina. Neuron-specific in the central and peripheral nervous system. Increased in the cerebrospinal fluid of Alzheimer disease patients (at protein level). Ref.6

Miscellaneous: Probably binds three calcium ions.

Sequence similarities: Belongs to the recoverin family.Contains 4 EF-hand domains.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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