Nicotinic Acetylcholine Receptor (Nachr) (CHRNB2) Antibody – Rabbit Polyclonal

nAChRB2: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in CHRNB2 are the cause of nocturnal frontal lobe epilepsy type 3 (ENFL3). ENFL3 is an autosomal dominant epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta- 2/CHRNB2 sub-subfamily.

Protein type: Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.

Chromosomal Location of Human Ortholog: 3 F1|3 39.19 cM

Cellular Component: external side of plasma membrane; membrane; nicotinic acetylcholine-gated receptor-channel complex; plasma membrane

Molecular Function: acetylcholine binding; acetylcholine receptor activity; acetylcholine-gated cation channel activity; drug binding; protein binding; protein heterodimerization activity

Biological Process: associative learning; B cell activation; behavioral response to nicotine; calcium ion transport; central nervous system neuron axonogenesis; central nervous system projection neuron axonogenesis; cognition; conditioned taste aversion; lateral geniculate nucleus development; learning; locomotory behavior; membrane depolarization; memory; negative regulation of action potential; neurological system process; optic nerve morphogenesis; positive regulation of B cell proliferation; positive regulation of dopamine secretion; positive regulation of synaptic transmission, dopaminergic; protein heterooligomerization; regulation of action potential; regulation of circadian sleep/wake cycle, non-REM sleep; regulation of circadian sleep/wake cycle, REM sleep; regulation of dendrite morphogenesis; regulation of dopamine metabolic process; regulation of dopamine secretion; regulation of membrane potential; regulation of synaptic transmission, dopaminergic; regulation of synaptogenesis; response to cocaine; response to ethanol; response to hypoxia; response to nicotine; sensory perception of pain; sensory perception of sound; signal transduction; smooth muscle contraction; social behavior; synaptic transmission involved in micturition; synaptic transmission, cholinergic; vestibulocochlear nerve development; visual learning; visual perception