• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Nicotinic Acetylcholine Receptor (Nachr) (CHRNB4) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS500064

Nicotinic acetylcholine receptors (nAChRs) are ionotropic, cholinergic receptors that are divided into 2 types; muscle type and neuronal type. Neuronal nAChRs are pentameric ion channels consisting of 5 identical (homopentamers) or different (heteropentamers)… More details

$495 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Nicotinic Acetylcholine Receptor (nAChR) (Chrnb4), Polyclonal Antibody
Full Product Name
Nicotinic Acetylcholine Receptor (nAChR) b4
Product Gene Name
anti-Chrnb4 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Predicted: Mouse, Rat
Form/Format
100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol.
Purity/Purification
Affinity Purified from Pooled Serum
Preparation and Storage
Store at -20 degree C
Molecular Weight
~52 kDa
3D Structure
ModBase 3D Structure for Q8R493
Immunogen
Fusion protein from the cytoplasmic loop of the beta 4 subunit of rat nAChR
Immunogen Species||Mouse
Purification Note
The antibody is prepared from pooled rabbit serum by affinity purification using a column to which the fusion protein immunogen was coupled.

Product Categories/Family for anti-Chrnb4 antibody

Neurotransmission
Applications Tested/Suitable for anti-Chrnb4 antibody
Western Blot (WB), Immunocytochemistry (ICC)
Application Notes for anti-Chrnb4 antibody
WB: 1:1000

Other Notes

Small volumes of anti-Chrnb4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Chrnb4 purchase

MBS500064 is an antibody targeting Chrnb4. Also known as Nicotinic Acetylcholine Receptor (nAChR) b4. Reactive in Predicted: Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Chrnb4. It may not necessarily be applicable to this product.

NCBI GI #
33563301
NCBI GeneID
108015
NCBI Accession #
NP_683746.1
UniProt Primary Accession #
Q8R493
UniProt Secondary Accession #
Q8VI06
UniProt Related Accession #
Q8R493
GenBank Nucleotide #
NM_148944.4
NCBI Official Full Name
neuronal acetylcholine receptor subunit beta-4
NCBI Official Synonym Full Names
cholinergic receptor, nicotinic, beta polypeptide 4
NCBI Official Symbol
Chrnb4
NCBI Official Synonym Symbols
Acrb4; Acrb-4
UniProt Protein Name
Neuronal acetylcholine receptor subunit beta-4
Protein Family
Neuronal acetylcholine receptor
UniProt Gene Name
Chrnb4
UniProt Synonym Gene Names
Acrb4
NCBI Protein Information
neuronal acetylcholine receptor subunit beta-4

UniProt Comments for Chrnb4

nAChRB4: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta- 4/CHRNB4 sub-subfamily.

Protein type: Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.

Chromosomal Location of Human Ortholog: 9|9 B

Cellular Component: membrane; neuron projection; nicotinic acetylcholine-gated receptor-channel complex; plasma membrane

Molecular Function: acetylcholine binding; acetylcholine receptor activity; acetylcholine-gated cation channel activity; drug binding; protein heterodimerization activity

Biological Process: behavioral response to nicotine; locomotory behavior; positive regulation of transmission of nerve impulse; protein heterooligomerization; regulation of action potential; regulation of membrane potential; regulation of smooth muscle contraction; response to nicotine; signal transduction; smooth muscle contraction; synaptic transmission involved in micturition; synaptic transmission, cholinergic
Show more

Research Articles on Chrnb4

1. Data suggest that the nicotinic acetylcholine receptor beta4 subunit (beta4 subunit) is not involved in ethanol responses.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Chrnb4 antibody

 Reference Product  PubMed Publications
 Chrna5 antibody  >140 publications with Chrnb4 and Chrna5
 Chrna7 antibody  >18 publications with Chrnb4 and Chrna7
 Chrna4 antibody  >16 publications with Chrnb4 and Chrna4
 Chrnb3 antibody  >15 publications with Chrnb4 and Chrnb3
 Chrna6 antibody  >13 publications with Chrnb4 and Chrna6
 Chrnb2 antibody  >12 publications with Chrnb4 and Chrnb2
 Chrna2 antibody  >10 publications with Chrnb4 and Chrna2
 Chrna9 antibody  >7 publications with Chrnb4 and Chrna9
 Chrna1 antibody  >3 publications with Chrnb4 and Chrna1
 Chrne antibody  >1 publications with Chrnb4 and Chrne

Pathways associated with anti-Chrnb4 antibody

 Products by Pathway  Pathway Diagram
 Acetylcholine Binding And Downstream Events Pathway antibodies  Acetylcholine Binding And Downstream Events Pathway Diagram
 Activation Of Nicotinic Acetylcholine Receptors Pathway antibodies  Activation Of Nicotinic Acetylcholine Receptors Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram
 Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway antibodies  Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway Diagram
 Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway antibodies  Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway Diagram
 Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway antibodies  Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-Chrnb4 antibody

 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >29 publications with Chrnb4 and Lung Neoplasms
 Brain Diseases Antibodies  >19 publications with Chrnb4 and Brain Diseases
 Adenocarcinoma Antibodies  >7 publications with Chrnb4 and Adenocarcinoma
 Disease Models, Animal Antibodies  >5 publications with Chrnb4 and Disease Models, Animal
 Seizures Antibodies  >5 publications with Chrnb4 and Seizures
 Substance Withdrawal Syndrome Antibodies  >4 publications with Chrnb4 and Substance Withdrawal Syndrome
 Cognition Disorders Antibodies  >3 publications with Chrnb4 and Cognition Disorders
 Memory Disorders Antibodies  >3 publications with Chrnb4 and Memory Disorders
 Movement Disorders Antibodies  >2 publications with Chrnb4 and Movement Disorders
 Anxiety Disorders Antibodies  >2 publications with Chrnb4 and Anxiety Disorders

Organs/Tissues associated with anti-Chrnb4 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >51 publications with Chrnb4 and Brain
 Embryonic Tissue Antibodies  >3 publications with Chrnb4 and Embryonic Tissue
 Sympathetic Ganglion Antibodies  >1 publications with Chrnb4 and Sympathetic Ganglion
 Eye Antibodies  >1 publications with Chrnb4 and Eye
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000