14-3-3 (Ser58) (YWHAB) Antibody – Rabbit Polyclonal

Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2

By similarity.

Subunit structure: Homodimer. Interacts with SSH1 and TORC2/CRTC2. Interacts with ABL1 (phosphorylated form); the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis. Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues. Interacts with GAB2, YAP1 and PRKCE (phosphorylated form). Interacts with SAMSN1

By similarity. Interacts with PKA-phosphorylated AANAT. Interacts with the phosphorylated (by AKT1) form of SRPK2

By similarity. Ref.5

Subcellular location: Cytoplasm. Melanosome

By similarity.

Post-translational modification: The alpha, brain-specific form differs from the beta form in being phosphorylated

By similarity. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion

By similarity.Isoform Short contains a N-acetylmethionine at position 1

By similarity.

Sequence similarities: Belongs to the 14-3-3 family.