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CNP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS502013

MBS502013 is an antibody targeting CNP. Also known as Anti-CNP (2,3-cyclic nucleotide-3-phosphodiesterase). Reactive in Mouse, human, rabbit, rat and sheep. Host: Rabbit. Rabbit polyclonal antibody More details

$435 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CNP (2,3-cyclic nucleotide-3-phosphodiesterase), Polyclonal Antibody
Full Product Name
Anti-CNP (2,3-cyclic nucleotide-3-phosphodiesterase)
Product Gene Name
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, human, rabbit, rat and sheep
Form/Format
50 ul neat serum
Purity/Purification
Neat serum
Specificity
Specific for the ~ 46k CNP protein in Western blots
Preparation and Storage
For long term storage -20 degree C is recommended. Stable at -20 degree C for at least 1 year.
Molecular Weight
46
Chromosome Location
Chromosome: 10; NC_005109.3 (88284045..88290604). Location: 10q32.1
3D Structure
ModBase 3D Structure for P13233
Antigen
Endogenous rabbit 2,3-cyclic nucleotide-3-phospho-diesterase
Immunogen Information
Endogenous rabbit 2,3 cyclic nucleotide-3-phospho-diesterase
Immunogen Species
Rabbit
Species Reactivity Note
The antibody has been directly tested for reactivity in Western blots with mouse, human, rabbit, rat and sheep tissues.
Biological Significance
2,3-cyclic nucleotide-3-phosphodiesterase (CNP) is a membrane bound, microtubule associated protein that is among the most abundant myelin proteins of the CNS. It is thought that CNP may serve as a regulator of tubulin polymerization and of microtubule distribution (Bifulco et al., 2002). It was recently found that CNP may also function as a possible linker protein anchoring microtubules to the plasma membrane via a 13 residue C-terminal CNP fragment (Bifulco et al., 2002, Esposito et al., 2008).
Applications Tested/Suitable for anti-CNP antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CNP antibody
Quality Control: Western blots performed on each lot.
WB: 1:1000
IHC: 1:1000 (formalin-fixed, Ramaswamy et al. 1990)

Testing Data of anti-CNP antibody

Rabbit Anti-CNP Polyclonal Antibody – Cat# MBS502013

Product References and Citations for anti-CNP antibody

• Bifulco et al. 2,3-Cyclic nucleotide 3-phosphodiesterase: a membrane bound, microtubule-associated protein and membrane anchor tubulin. PNAS 99:1807-12, 2002
• Esposito C, Scrima M, Carotenuto A, Tedeschi A, Rovero P, D'Ebifulco M, D'Errico G, Malfitano AM, D'Ursi AM (2008) Structures and micelle locations of the nonlipidated and lipidated C-terminal anchor of 2,3-Cyclic nucleotide 3-phosphodiesterase. Biochemistry 47(1): 308-319.

Other Notes

Small volumes of anti-CNP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CNP. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
2',3'-cyclic-nucleotide 3'-phosphodiesterase
NCBI Official Synonym Full Names
2',3'-cyclic nucleotide 3' phosphodiesterase
NCBI Official Symbol
Cnp
NCBI Official Synonym Symbols
CNPF; CNPI; Cnp1; CNPII
UniProt Protein Name
2',3'-cyclic-nucleotide 3'-phosphodiesterase
UniProt Gene Name
Cnp
UniProt Synonym Gene Names
Cnp1; CNP; CNPase
UniProt Entry Name
CN37_RAT
NCBI Protein Information
2',3'-cyclic-nucleotide 3'-phosphodiesterase; CNPase

NCBI Summary for CNP

microtubule-binding protein that promotes microtubule assembly and may regulate cellular distribution of microtubules [RGD, Feb 2006]

UniProt Comments for CNP

Function: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin

By similarity.

Catalytic activity: Nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate.

Subunit structure: Exists as monomers and homodimers

By similarity.

Subcellular location: Membrane; Lipid-anchor. Melanosome

By similarity. Note: Firmly bound to membrane structures of brain white matter.

Sequence similarities: Belongs to the cyclic nucleotide phosphodiesterase family.

Sequence caution: The sequence AAA40939.1 differs from that shown. Reason: Frameshift at several positions. The sequence AAA40939.1 differs from that shown. Reason: Sequencing errors.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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