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DOPA Decarboxylase, Bovine (DDC) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS502020

MBS502020 is an antibody targeting DDC. Also known as Anti-DOPA Decarboxylase. Reactive in Rat. Host: Rabbit. Affinity purified rabbit polyclonal antibody More details

$495 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DOPA Decarboxylase, Bovine (DDC), Polyclonal Antibody
Full Product Name
Anti-DOPA Decarboxylase
Product Gene Name
anti-DDC antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Rat
Form/Format
100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
Purity/Purification
Affinity Purified (Prepared from rabbit serum by affinity purification using an AminoLink Plus column matrix to which purified, recombinant bovine DDC was coupled.)
Specificity
Specific for the ~55k DDC protein.
Preparation and Storage
For long term storage -20 degree C is recommended. Stable at -20 degree C for at least 1 year.
Molecular Weight
55
Chromosome Location
Chromosome: 4; AC_000161.1 (5276966..5347715). Location: chromosome: 4
3D Structure
ModBase 3D Structure for P27718
Antigen
SDS denatured, recombinant bovine aromatic DOPA decarboxylase (DDC) expressed in E. coli and purified from inclusion bodies.
Immunogen Information
SDS denatured, recombinant bovine aromatic DOPA decarboxylase expressed in E. coli and purified from inclusion bodies
Immunogen Species
Bovine
Reactivity Assumed Based on 100% Sequence Homology
Bovine
Species Reactivity Note
The antibody has been directly tested for reactivity in Western blots in rat tissues.
Biological Significance
DOPA decarboxylase (aromatic L-amino acid decarboxylase, AADC; DDC) catalyzes the second reaction in the biosynthesis of catecholamines and serotonin (Waymire and Haycock, 2002; Berry et al., 1996; Haycock et al., 2003). It is also involved in the biosynthesis of trace amines. DDC antibodies can therefore be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson's disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999).
Applications Tested/Suitable for anti-DDC antibody
Western Blot (WB)
Application Notes for anti-DDC antibody
Quality Control: Western blots performed on each lot.
WB: 1:1000

Testing Data of anti-DDC antibody

Rabbit Anti-DDC Polyclonal Antibody – Cat# MBS502020

Product References and Citations for anti-DDC antibody

• Berry MD, Juorio AV, Li XM, Boulton AA (1996) Aromatic L-amino acid decarboxylase: a neglected and misunderstood enzyme. Neurochem Res 21:1075-1087.
• Haycock JW, Becker L, Ang L, Furukawa Y, Hornykiewicz O, Kish SJ (2003) Marked disparity between age-related changes in dopamine and other presynaptic dopaminergic markers in human striatum. J Neurochem 87:574-585.
• Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L, Adams V, Furukawa Y, Haycock JW (2001) Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology 24:561-567.
• Waymire JC, Haycock JW (2002) Lack of regulation of aromatic L-amino acid decarboxylase in intact bovine chromaffin cells. J Neurochem 81:589-593.
• Zhu MY, Klimek V, Haycock JW, Ordway GA (2000) Quantitation of tyrosine hydroxylase protein in the locus coeruleus from postmortem human brain. J Neurosci Meth 99:37-44.

Other Notes

Small volumes of anti-DDC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DDC. It may not necessarily be applicable to this product.

NCBI GI #
27806901
NCBI GeneID
280762
NCBI Accession #
NP_776332.1
UniProt Primary Accession #
P27718
UniProt Secondary Accession #
Q0V8S3
UniProt Related Accession #
P27718
GenBank Nucleotide #
NM_173907.2
NCBI Official Full Name
aromatic-L-amino-acid decarboxylase
NCBI Official Synonym Full Names
dopa decarboxylase (aromatic L-amino acid decarboxylase)
NCBI Official Symbol
DDC
UniProt Protein Name
Aromatic-L-amino-acid decarboxylase
UniProt Synonym Protein Names
DOPA decarboxylase
Protein Family
Aromatic-L-amino-acid decarboxylase
UniProt Gene Name
DDC
UniProt Synonym Gene Names
AADC; DDC
UniProt Entry Name
DDC_BOVIN
NCBI Protein Information
aromatic-L-amino-acid decarboxylase; AADC; aromatic L-amino acid decarboxylase

UniProt Comments for DDC

Function: Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Catalytic activity: L-dopa = dopamine + CO2.5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2.

Cofactor: Pyridoxal phosphate.

Pathway: Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.

Subunit structure: Homodimer.

Sequence similarities: Belongs to the group II decarboxylase family.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DDC antibody

 Reference Product  PubMed Publications
 DBH antibody  >32 publications with DDC and DBH
 COMT antibody  >28 publications with DDC and COMT
 TAT antibody  >10 publications with DDC and TAT
 MAOA antibody  >7 publications with DDC and MAOA
 PAH antibody  >5 publications with DDC and PAH
 TYR antibody  >5 publications with DDC and TYR
 TPH1 antibody  >4 publications with DDC and TPH1
 MAOB antibody  >4 publications with DDC and MAOB

Pathways associated with anti-DDC antibody

 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway antibodies  Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway Diagram
 Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway antibodies  Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram

Diseases associated with anti-DDC antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >161 publications with DDC and Neoplasms
 Disease Models, Animal Antibodies  >106 publications with DDC and Disease Models, Animal
 Liver Diseases Antibodies  >102 publications with DDC and Liver Diseases
 Brain Diseases Antibodies  >88 publications with DDC and Brain Diseases
 Death Antibodies  >73 publications with DDC and Death
 Poisoning Antibodies  >56 publications with DDC and Poisoning
 Mental Disorders Antibodies  >55 publications with DDC and Mental Disorders
 Movement Disorders Antibodies  >52 publications with DDC and Movement Disorders
 Parkinsonian Disorders Antibodies  >48 publications with DDC and Parkinsonian Disorders
 Necrosis Antibodies  >40 publications with DDC and Necrosis

Organs/Tissues associated with anti-DDC antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >255 publications with DDC and Brain
 Kidney Antibodies  >64 publications with DDC and Kidney
 Intestine Antibodies  >28 publications with DDC and Intestine
 Pancreas Antibodies  >18 publications with DDC and Pancreas
 Reticulum Antibodies  >9 publications with DDC and Reticulum
 Uncharacterized Tissue Antibodies  >1 publications with DDC and Uncharacterized Tissue
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