GABAA Receptor Beta2 (GABRB2) Antibody

Name: GABRB2 Antibody; MyBioSource
Brand: MyBioSource
SKU: MBS502051
Price: 495 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS502051

MBS502051 is an antibody targeting GABRB2. Also known as Anti-GABAA Receptor, beta2-Subunit. Affinity purified rabbit polyclonal antibody More details

$495 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GABAA Receptor beta2 (GABRB2), Antibody

Full Product Name

Anti-GABAA Receptor, beta2-Subunit

Product Gene Name

anti-GABRB2 antibody

Form/Format

100ul in 10mM HEPES (pH 7.5), 150mM NaCl, 100ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western blots.

Preparation and Storage

Ships on blue ice. For long term storage -80°C is recommended, but shorter term storage at -20°C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol. Stock solutions are stable for a minimum of 1 year at -20°C.

Molecular Weight

Chromosome Location

Chromosome: 10; NC_005109.3 (27816796..28032603). Location: 10q21

3D Structure

ModBase 3D Structure for P63138

Antibody Specificity

Specific for the ~50k to 56k Beta₂-subunit of the GABA_A-R in Western blots of rat brain memebrane fractions. Also recognizes the Beta₂subunit of the GABA_A-R in bovine, human and mouse brain extracts.

Applications Tested/Suitable for anti-GABRB2 antibody

Dot Blots (DB), Western Blots (WB)

Application Notes for anti-GABRB2 antibody

DB: 1:1000
WB: 1:1000

Product References and Citations for anti-GABRB2 antibody

• McKernan RM, et al. (2000) Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor alpha1-subtype. Nature Neurosci 3:587-592.
• McKernan RM, et al. (2000) Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor alpha1-subtype. Nature Neurosci 3:587-592.
• Ogris W, Pöltl A, Hauer B, Ernst M, Oberto A, Wulff P, Höger H, Wisden W, Sieghart W (2004) Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABAA receptor gamma2-subunit. Biochem Pharmacol 68:1621-1629
• Olsen RW, Tobin AJ (1990) Molecular biology of GABAA receptors. FASEB 4:1469-1480.
• Pöltl A, Hauer B, Fuchs K, Tretter V, Sieghart W (2003) Subunit composition and quantitative importance of GABAA receptor subtypes in the cerebellum of mouse and rat. J Neurochem 87:1444-1455.

Other Notes

Small volumes of anti-GABRB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GABRB2. It may not necessarily be applicable to this product.

NCBI GI #

6978869

NCBI GeneID

25451

NCBI Accession #

NP_037089.1

UniProt Primary Accession #

P63138

UniProt Secondary Accession #

P15432

UniProt Related Accession #

P63138

GenBank Nucleotide #

NM_012957.2

NCBI Official Full Name

gamma-aminobutyric acid receptor subunit beta-2

NCBI Official Synonym Full Names

gamma-aminobutyric acid (GABA) A receptor, beta 2

NCBI Official Symbol

Gabrb2

NCBI Official Synonym Symbols

GARB2

UniProt Protein Name

Gamma-aminobutyric acid receptor subunit beta-2

UniProt Synonym Protein Names

GABA(A) receptor subunit beta-2

Protein Family

Gamma-aminobutyric acid receptor

UniProt Gene Name

Gabrb2

UniProt Synonym Gene Names

Gabrb-2

UniProt Entry Name

GBRB2_RAT

NCBI Protein Information

gamma-aminobutyric acid receptor subunit beta-2; GABA(A) receptor subunit beta-2; Gamma-aminobutyric acid receptor beta 2; gamma-aminobutyric acid receptor, subunit beta 2; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2

NCBI Summary for GABRB2

subunit of GABA-A receptors, which induce inhibitory postsynaptic currents; mediates desentization [RGD, Feb 2006]

UniProt Comments for GABRB2

Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Subunit structure: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents. Ref.3 Ref.4

Subcellular location: Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Sequence similarities: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB2 sub-subfamily. [View classification]

Research Articles on GABRB2

1. These studies identify a novel gephyrin-binding motif in GABA(A) R beta2 and beta3 large cytoplasmic loops.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GABRB2 antibody

Products by Pathway	Pathway Diagram
GABA A Receptor Activation Pathway antibodies	GABA A Receptor Activation Pathway Diagram
GABA Receptor Activation Pathway antibodies	GABA Receptor Activation Pathway Diagram
GABAergic Synapse Pathway antibodies	GABAergic Synapse Pathway Diagram
GABAergic Synapse Pathway antibodies	GABAergic Synapse Pathway Diagram
Ion Channel Transport Pathway antibodies	Ion Channel Transport Pathway Diagram
Ligand-gated Ion Channel Transport Pathway antibodies	Ligand-gated Ion Channel Transport Pathway Diagram
Morphine Addiction Pathway antibodies	Morphine Addiction Pathway Diagram
Morphine Addiction Pathway antibodies	Morphine Addiction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-GABRB2 antibody

Disease Name	Pubmed Publications
Schizophrenia Antibodies	>25 publications with GABRB2 and Schizophrenia
Nervous System Diseases Antibodies	>13 publications with GABRB2 and Nervous System Diseases
Central Nervous System Diseases Antibodies	>13 publications with GABRB2 and Central Nervous System Diseases
Brain Diseases Antibodies	>12 publications with GABRB2 and Brain Diseases
Seizures Antibodies	>11 publications with GABRB2 and Seizures
Epilepsy Antibodies	>10 publications with GABRB2 and Epilepsy
Substance-Related Disorders Antibodies	>7 publications with GABRB2 and Substance-Related Disorders
Ataxia Antibodies	>2 publications with GABRB2 and Ataxia
Inflammation Antibodies	>2 publications with GABRB2 and Inflammation
Brain Injuries Antibodies	>1 publications with GABRB2 and Brain Injuries

Organs/Tissues associated with anti-GABRB2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>49 publications with GABRB2 and Brain
Mixed Antibodies	>3 publications with GABRB2 and Mixed