Rabbit Anti-GRIPAP1 Polyclonal Antibody – Cat# MBS502068

GRIPAP1 Antibody – Rabbit Polyclonal

Name: GRIPAP1 Antibody; Polyclonal; Rabbit; Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS502068
Price: 495 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS502068

MBS502068 is an antibody targeting GRIPAP1. Also known as Anti-GRASP. Reactive in Rat. Host: Rabbit. Affinity purified rabbit polyclonal antibody More details

$495 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GRASP (GRIPAP1), Polyclonal Antibody

Full Product Name

Anti-GRASP

Product Gene Name

anti-GRIPAP1 antibody

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Rat

Form/Format

100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

Purity/Purification

Affinity Purified (Prepared from rabbit serum by affinity purification via chromatography on an affinity column prepared with the C-terminal peptide used as antigen.)

Specificity

Specific for the ~95k GRASP protein.

Preparation and Storage

Store at -20 degree C; stable for at least one year.

Molecular Weight

Chromosome Location

Chromosome: X; NC_005120.3 (16305164..16334935, complement). Location: Xq13

3D Structure

ModBase 3D Structure for Q9JHZ4

Antigen

Peptide corresponding to amino acid residues from the C-terminal region of rat GRASP, conjugated to keyhole limpet hemocyanin (KLH).

Immunogen Information

Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH

Immunogen Species

Rat

Reactivity Assumed Based on 100% Sequence Homology

Bovine, canine, human and mouse

Species Reactivity Note

The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, canine, human and mouse based on the fact that these species have 100% homology with the amino acid sequence used as antigen.

Biological Significance

PDZ domain-containing proteins, such as PSD-95 and GRIP are thought to play key roles in glutamate receptor plasticity. GRIP-associated proteins (GRASPs) that bind to distinct PDZ domains within GRIP also play key roles in regulation of glutamate receptor function. GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo (Scannevin and Huganir, 2000). Recent work suggests that GRASP-1 may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity (Ye et al., 2000).

Applications Tested/Suitable for anti-GRIPAP1 antibody

Western Blot (WB)

Application Notes for anti-GRIPAP1 antibody

Quality Control: Western blots performed on each lot.
WB: 1:1000

Product References and Citations for anti-GRIPAP1 antibody

• Scannevin RH, Huganir RL (2000) Postsynaptic organization and regulation of excitatory synapses. Nat Rev Neurosci 1:133-141.
• Ye B, Liao DZ, Zhang XQ, Zhang PS, Dong HL, Huganir RL (2000) GRASP-1: A neuronal RasGEF associated with the AMPA receptor/GRIP complex. Neuron 26:603-617.

Other Notes

Small volumes of anti-GRIPAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GRIPAP1. It may not necessarily be applicable to this product.

NCBI GI #

16758652

NCBI GeneID

116493

NCBI Accession #

NP_446259.1

UniProt Primary Accession #

Q9JHZ4

UniProt Secondary Accession #

Q9JHZ3

UniProt Related Accession #

Q9JHZ4

GenBank Nucleotide #

NM_053807.1

NCBI Official Full Name

GRIP1-associated protein 1

NCBI Official Synonym Full Names

GRIP1 associated protein 1

NCBI Official Symbol

Gripap1

NCBI Official Synonym Symbols

Grasp1

UniProt Protein Name

GRIP1-associated protein 1

Protein Family

GRIP1-associated protein

UniProt Gene Name

Gripap1

UniProt Synonym Gene Names

Grasp1; GRASP-1

UniProt Entry Name

GRAP1_RAT

NCBI Protein Information

GRIP1-associated protein 1; GRASP-1; GRIP-associated protein 1

NCBI Summary for GRIPAP1

a neuronal rasGEF that may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity [RGD, Feb 2006]

UniProt Comments for GRIPAP1

Subunit structure: Interacts with GRIP1, GRIP2 and AMPA receptors. Ref.1

Subcellular location: Early endosome

By similarity.

Tissue specificity: Expressed in the central nervous system; especially in neurons. Ref.1

Post-translational modification: Proteolytically cleaved by caspase-3. A minor C-terminal proteolytic fragment of 30 kDa is produced. Ref.1

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-GRIPAP1 antibody

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>1 publications with GRIPAP1 and Cardiovascular Diseases

Organs/Tissues associated with anti-GRIPAP1 antibody

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>1 publications with GRIPAP1 and Heart
Lung Antibodies	>1 publications with GRIPAP1 and Lung
Brain Antibodies	>1 publications with GRIPAP1 and Brain