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Potassium Channel, Voltage-Gated, Kv3.1 Subunit (Ser503) (KCNC1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS502105

MBS502105 is an antibody targeting KCNC1. Also known as Anti-Phospho-Ser503 Kv3.1, Voltage-Gated, Potassium Channel. Reactive in Rat, mouse. Host: Rabbit. Affinity purified rabbit polyclonal antibody More details

$495 / 0.1 mL +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Potassium Channel, Voltage-Gated, Kv3.1 Subunit (Ser503) (KCNC1), Polyclonal Antibody
Full Product Name
Anti-Phospho-Ser503 Kv3.1, Voltage-Gated, Potassium Channel
Product Gene Name
anti-KCNC1 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Rat, mouse
Form/Format
100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
Purity/Purification
Affinity Purified (Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.)
Specificity
Specific for the ~100k Kv3.1 voltage-gated potassium channel protein phosphorylated at Ser503.
Preparation and Storage
For long term storage -20 degree C is recommended. Stable at -20 degree C for at least 1 year.
Molecular Weight
100
Chromosome Location
Chromosome: 1; NC_005100.3 (103499689..103541476). Location: 1q22
3D Structure
ModBase 3D Structure for P25122
Antigen
Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser503 of the voltage-gated potassium channel Kv3.1, conjugated to keyhole limpet hemocyanin (KLH).
Immunogen Information
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser503 conjugated to KLH
Immunogen Species
Rat
Species Reactivity Note
The antibody has been directly tested for reactivity in Western blots with rat and mouse tissue.
Biological Significance
Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999).Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).
Applications Tested/Suitable for anti-KCNC1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-KCNC1 antibody
Quality Control: Western blots performed on each lot.
WB: 1:1000
IHC (frozen sections; unpublished observations): 1:1000

Testing Data of anti-KCNC1 antibody

Rabbit Anti-KCNC1 Polyclonal Antibody – Cat# MBS502105

Product References and Citations for anti-KCNC1 antibody

• Blaine JT, Ribera AB (1998) Heteromultimeric potassium channels formed by members of the Kv2 subfamily. J Neurosci 18:9585-9593.
• Burger C, Ribera AB (1996) Xenopus spinal neurons express Kv2 potassium channel transcripts during embryonic development. J Neurosci 16:1412-1421. Gan L, Hahn SJ, Kaczmarek LK (1999) Cell type-specific expression of the Kv3.1 gene is mediated by a negative element in the 5' untranslated region of the Kv3.1 promoter. J Neurochem 73:1350-1362.
• Maletic-Savatic M, Lenn NJ, Trimmer JS (1995) Differential spatiotemporal expression of K+ channel polypeptides in rat hippocampal neurons developing in situ and in vitro. J Neurosci 15:3840-3851.
• Pongs O (1999) Voltage-gated potassium channels: from hyperexcitability to excitement. FEBS Lett 452:31-35.
• von Hehn CA, Bhattacharjee A, Kaczmarek LK (2004) Loss of Kv3.1 tonotopicity and alterations in cAMP response element-binding protein signaling in central auditory neurons of hearing impaired mice. J Neurosci 24:1936-1940.

Other Notes

Small volumes of anti-KCNC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNC1. It may not necessarily be applicable to this product.

NCBI GI #
6981122
NCBI GeneID
25327
NCBI Accession #
NP_036988.1
UniProt Primary Accession #
P25122
UniProt Related Accession #
P25122
GenBank Nucleotide #
NM_012856.1
NCBI Official Full Name
potassium voltage-gated channel subfamily C member 1
NCBI Official Synonym Full Names
potassium voltage gated channel, Shaw-related subfamily, member 1
NCBI Official Symbol
Kcnc1
NCBI Official Synonym Symbols
Kv4; Kv3.1; KShIIIB; NGK2-KV4
UniProt Protein Name
Potassium voltage-gated channel subfamily C member 1
UniProt Synonym Protein Names
NGK2; RAW2; Voltage-gated potassium channel subunit Kv3.1; Voltage-gated potassium channel subunit Kv4
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
Kcnc1
UniProt Entry Name
KCNC1_RAT
NCBI Protein Information
potassium voltage-gated channel subfamily C member 1; NGK2; RAW2; potassium channel gene 1; voltage-gated potassium channel subunit Kv4; voltage-gated potassium channel subunit Kv3.1

NCBI Summary for KCNC1

voltage gated potassium channel; functions as a delayed rectifier K+ channel [RGD, Feb 2006]

UniProt Comments for KCNC1

Function: This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Subunit structure: Heteromultimer with KCNG3, KCNG4 and KCNV2

By similarity.

Subcellular location: Membrane; Multi-pass membrane protein.

Tissue specificity: Brain.

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Sequence similarities: Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily. [View classification]
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Research Articles on KCNC1

1. high-affinity multimeric binding between the Kv3.1 T1 domain and KIF5B requires three basic residues in the KIF5B tail. Kv3.1 T1 competes with the motor domain and microtubules, but not with kinesin light chain 1 (KLC1), for binding to the KIF5B tail.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KCNC1 antibody

 Reference Product  PubMed Publications
 Kcnc2 antibody  >3 publications with KCNC1 and Kcnc2
 Kcnq2 antibody  >2 publications with KCNC1 and Kcnq2

Pathways associated with anti-KCNC1 antibody

 Products by Pathway  Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram

Diseases associated with anti-KCNC1 antibody

 Disease Name  Pubmed Publications
 Ear Diseases Antibodies  >4 publications with KCNC1 and Ear Diseases
 Ataxia Antibodies  >3 publications with KCNC1 and Ataxia
 Disease Models, Animal Antibodies  >3 publications with KCNC1 and Disease Models, Animal
 Congenital Abnormalities Antibodies  >3 publications with KCNC1 and Congenital Abnormalities
 Brain Diseases Antibodies  >2 publications with KCNC1 and Brain Diseases
 Neoplasms Antibodies  >2 publications with KCNC1 and Neoplasms

Organs/Tissues associated with anti-KCNC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >32 publications with KCNC1 and Brain
 Inner Ear Antibodies  >1 publications with KCNC1 and Inner Ear
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