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Stargazin (CACNG2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS502114

Description: Affinity purified rabbit polyclonal antibodyBiological Significance: Stargazin is a member of the transmembrane AMPAR regulatory proteins (TARP) family and is involved in glutamate receptor trafficking. It has been recently demonstrated (Tomita… More details

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Product Overview

Online Datasheet in PDF
Product Name
Stargazin (CACNG2), Polyclonal Antibody
Full Product Name
Anti-Stargazin
Product Gene Name
anti-CACNG2 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Tested: Rat
Expected: Mouse
Form/Format
100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
Purity/Purification
Prepared from pooled rabbit serum by affinity purification via chromatography on an affinity column to which the C-terminal peptide used as immunogen was coupled.
Specificity
Specific for the ~36kDa stargazin protein.
Preparation and Storage
Store at -20°C, stable for one year. Avoid freeze/thaw cycles.
Molecular Weight
36 kDa
Chromosome Location
Chromosome: 15; NC_000081.6 (77993623..78119280, complement). Location: 15 E1; 15 36.92 cM
3D Structure
ModBase 3D Structure for O88602
Immunogen
Peptide corresponding to amino acid residues from the C-terminal region of rat stargazin, conjugated to keyhole limpet hemocyanin (KLH).
Quality Control Tests
Western blots performed on each lot.
Applications Tested/Suitable for anti-CACNG2 antibody
Western Blot (WB)
Application Notes for anti-CACNG2 antibody
WB: 1:1000

Western Blot (WB) of anti-CACNG2 antibody

Western blot of rat synaptic membrane (SPM) showing specific immunolabeling of the ~36 kDa stargazin protein.
Rabbit Anti-CACNG2 Polyclonal Antibody – Cat# MBS502114

Product References and Citations for anti-CACNG2 antibody

• Tomita S, Adesnik H, Sekiguchi M, Zhang W, Wada K, Howe JR, Nicoll RA, Bredt DS,(2005) Stargazin modulates AMPA receptor gating and trafficking by distinct domains. Nature 435: 1052-1058.
• Priel A, Kolleker A, Ayalon G, Gillor M, Osten P, Stern-Bach Y. (2005) Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors. J. Neurosci. 25, 2682-2686.
• Choi, J, Ko J, Park E, Lee JR, Yoon J, Lim S, Kim E, Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95.J Biol Chem. 2002 Apr 5;277(14):12359-63.

Other Notes

Small volumes of anti-CACNG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CACNG2 purchase

MBS502114 is an antibody targeting CACNG2. Also known as Anti-Stargazin. Reactive in Tested: Rat
Expected: Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CACNG2. It may not necessarily be applicable to this product.

NCBI GI #
6680826
NCBI GeneID
12300
NCBI Accession #
NP_031609.1
UniProt Primary Accession #
O88602
UniProt Related Accession #
O88602
GenBank Nucleotide #
NM_007583.2
NCBI Official Full Name
voltage-dependent calcium channel gamma-2 subunit
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, gamma subunit 2
NCBI Official Symbol
Cacng2
NCBI Official Synonym Symbols
stg; wag; waggler; AW060990; stargazer; stargazin; B230105C07Rik; B930041E13Rik
UniProt Protein Name
Voltage-dependent calcium channel gamma-2 subunit
UniProt Synonym Protein Names
Neuronal voltage-gated calcium channel gamma-2 subunit; Stargazin; Transmembrane AMPAR regulatory protein gamma-2
Protein Family
Voltage-dependent calcium channel
UniProt Gene Name
Cacng2
UniProt Synonym Gene Names
Stg; TARP gamma-2
UniProt Entry Name
CCG2_MOUSE
NCBI Protein Information
voltage-dependent calcium channel gamma-2 subunit; TARP gamma 2; TARP gamma-2; transmembrane AMPAR regulatory protein gamma-2; neuronal voltage-gated calcium channel gamma-2 subunit

UniProt Comments for CACNG2

Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state

By similarity.

Subunit structure: The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97. May interact with GOPC. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with GRIA1

By similarity. Ref.2 Ref.3

Subcellular location: Membrane; Multi-pass membrane protein.

Tissue specificity: Brain.

Post-translational modification: Phosphorylation of Thr-321 by PKA impairs interaction with DLG1 and DLG4.

Involvement in disease: Defects in Cacng2 cause the stargazer (stg) phenotype. Stg mice have spike-wave seizures characteristic of absence epilepsy, with accompanying defects in the cerebellum and inner ear.

Sequence similarities: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
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Research Articles on CACNG2

1. The combined loss of the AMPA receptor auxiliary TARPg-2 subunit and the GluK5 subunit leads to early mouse lethality.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CACNG2 antibody

 Reference Product  PubMed Publications
 Cacng4 antibody  >4 publications with CACNG2 and Cacng4
 Cacng3 antibody  >2 publications with CACNG2 and Cacng3
 Gria4 antibody  >1 publications with CACNG2 and Gria4

Pathways associated with anti-CACNG2 antibody

 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway antibodies  Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway antibodies  Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway Diagram

Diseases associated with anti-CACNG2 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >28 publications with CACNG2 and Nervous System Diseases
 Epilepsy Antibodies  >25 publications with CACNG2 and Epilepsy
 Brain Diseases Antibodies  >21 publications with CACNG2 and Brain Diseases
 Seizures Antibodies  >12 publications with CACNG2 and Seizures
 Memory Disorders Antibodies  >3 publications with CACNG2 and Memory Disorders
 Learning Disorders Antibodies  >3 publications with CACNG2 and Learning Disorders
 Mood Disorders Antibodies  >3 publications with CACNG2 and Mood Disorders
 Movement Disorders Antibodies  >2 publications with CACNG2 and Movement Disorders
 Delirium Antibodies  >1 publications with CACNG2 and Delirium
 Neurodegenerative Diseases Antibodies  >1 publications with CACNG2 and Neurodegenerative Diseases

Organs/Tissues associated with anti-CACNG2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >83 publications with CACNG2 and Brain
 Spinal Cord Antibodies  >2 publications with CACNG2 and Spinal Cord
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