Rabbit Anti-STXBP1 Polyclonal Antibody – Cat# MBS502183

Munc18-1 (Ser241) (STXBP1) Antibody – Rabbit Polyclonal

Name: STXBP1 Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS502183
Price: 495 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS502183

MBS502183 is an antibody targeting STXBP1. Also known as Anti-Phospho-Ser241 Munc18-1. Reactive in Mouse. Host: Rabbit. Affinity purified rabbit polyclonal antibody More details

$495 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Munc18-1 (Ser241) (STXBP1), Polyclonal Antibody

Full Product Name

Anti-Phospho-Ser241 Munc18-1

Product Gene Name

anti-STXBP1 antibody

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Mouse

Form/Format

100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug BSA per ml and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

Purity/Purification

Affinity Purified (Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.)

Specificity

Specific for the ~65k Munc18-1 protein phosphorylated at Ser241. Immunolabeling is blocked by the treatment of the lysate with lambda phosphatase (30 minutes, 800 units / 1 mg protein).

Preparation and Storage

For long term storage -20 degree C is recommended. Stable at -20 degree C for at least 1 year.

Molecular Weight

Chromosome Location

Chromosome: 2; NC_000068.7 (32787607..32847237, complement). Location: 2 B; 2 22.09 cM

3D Structure

ModBase 3D Structure for O08599

Antigen

Phosphopeptide corresponding to amino acid residues surrounding the phospho- Ser241 of mouse Munc18-1.

Immunogen Information

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser241 conjugated to KLH

Immunogen Species

Mouse

Reactivity Assumed Based on 100% Sequence Homology

Bovine, canine, chicken, human, non-human primates, rat and sheep

Species Reactivity Note

The antibody has been directly tested for reactivity in Western blots with mouse tissue. It is anticipated that the antibody will react with bovine, canine, human, non-human primates, rat, and sheep based on the fact that these species have 100% homology with the amino acid sequence used as antigen.

Biological Significance

Munc-18 (mammalian homologue of Unc-18) is a protein that is thought to be involved in regulating exocytosis due, at least in part, to it ability to bind syntaxin (Ciufo et al., 2005). Munc18-1 is a neuron-specific member of the Sec1/Munc18 protein family that binds to syntaxin1A and is thought to stabilize the complex (Liu et al., 2004). The function of Munc18-1 is thought to be regulated by phosphorylation.

Applications Tested/Suitable for anti-STXBP1 antibody

Western Blot (WB)

Application Notes for anti-STXBP1 antibody

Quality Control: Western blots performed on each lot.
WB: 1:1000

Product References and Citations for anti-STXBP1 antibody

• Ciufo LF, Barclay JW, Burgoyne RD, Morgan A (2005) Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions. Mol Biol Cell 16:470-482.
• Liu J, Ernst SA, Gladycheva SE, Lee YY, Lentz SI, Ho CS, Li Q, Stuenkel EL (2004) Fluorescence resonance energy transfer reports properties of syntaxin1a interaction with Munc18-1 in vivo. J Biol Chem 279:55924-55936.

Other Notes

Small volumes of anti-STXBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for STXBP1. It may not necessarily be applicable to this product.

NCBI GI #

165972307

NCBI GeneID

20910

NCBI Accession #

NP_001107041.1

UniProt Primary Accession #

O08599

UniProt Secondary Accession #

Q5WAC6; Q8VD51; A2ARS2; A2ARS3; A2ARS4

UniProt Related Accession #

O08599

GenBank Nucleotide #

NM_001113569.1

NCBI Official Full Name

syntaxin-binding protein 1 isoform a

NCBI Official Synonym Full Names

syntaxin binding protein 1

NCBI Official Symbol

Stxbp1

NCBI Official Synonym Symbols

Ms10g; nsec1; N-sec1; Sxtbp1; Unc18h; MMS10-G; Rb-sec1; Unc18-1; AI317162; AI326233; Munc-18a; Munc18-1

UniProt Protein Name

Syntaxin-binding protein 1

UniProt Synonym Protein Names

Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A

Protein Family

Syntaxin-binding protein

UniProt Gene Name

Stxbp1

UniProt Synonym Gene Names

Unc18-1; Unc-18A

UniProt Entry Name

STXB1_MOUSE

NCBI Protein Information

syntaxin-binding protein 1; unc-18A; unc-18-1; UNC-18 homolog; protein unc-18 homolog 1; protein unc-18 homolog A; minisatellite 10g detected by probe MMS10

UniProt Comments for STXBP1

Function: May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions

By similarity.

Subunit structure: Binds SYTL4

By similarity. Interacts with STX1A

By similarity.

Sequence similarities: Belongs to the STXBP/unc-18/SEC1 family.

Sequence caution: The sequence CAM20726.1 differs from that shown. Reason: Erroneous gene model prediction.

Research Articles on STXBP1

1. Syntaxin binding protein 1 is not required for allergic inflammation via IgE-mediated mast cell activation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-STXBP1 antibody

Reference Product	PubMed Publications
Stx1a antibody	>23 publications with STXBP1 and Stx1a
Snap25 antibody	>10 publications with STXBP1 and Snap25
Syt1 antibody	>3 publications with STXBP1 and Syt1
Rab3a antibody	>3 publications with STXBP1 and Rab3a
Cplx1 antibody	>1 publications with STXBP1 and Cplx1
Unc13b antibody	>1 publications with STXBP1 and Unc13b

Pathways associated with anti-STXBP1 antibody

Products by Pathway	Pathway Diagram
Acetylcholine Neurotransmitter Release Cycle Pathway antibodies	Acetylcholine Neurotransmitter Release Cycle Pathway Diagram
EGFR1 Signaling Pathway antibodies	EGFR1 Signaling Pathway Diagram
GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies	GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram
Glutamate Neurotransmitter Release Cycle Pathway antibodies	Glutamate Neurotransmitter Release Cycle Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram
Integration Of Energy Metabolism Pathway antibodies	Integration Of Energy Metabolism Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Neuronal System Pathway antibodies	Neuronal System Pathway Diagram
Neurotransmitter Release Cycle Pathway antibodies	Neurotransmitter Release Cycle Pathway Diagram
Norepinephrine Neurotransmitter Release Cycle Pathway antibodies	Norepinephrine Neurotransmitter Release Cycle Pathway Diagram

Diseases associated with anti-STXBP1 antibody

Disease Name	Pubmed Publications
Brain Diseases Antibodies	>33 publications with STXBP1 and Brain Diseases
Neurobehavioral Manifestations Antibodies	>7 publications with STXBP1 and Neurobehavioral Manifestations
Epilepsies, Myoclonic Antibodies	>5 publications with STXBP1 and Epilepsies, Myoclonic
Inflammation Antibodies	>2 publications with STXBP1 and Inflammation
Memory Disorders Antibodies	>1 publications with STXBP1 and Memory Disorders
Cocaine-Related Disorders Antibodies	>1 publications with STXBP1 and Cocaine-Related Disorders
Immune System Diseases Antibodies	>1 publications with STXBP1 and Immune System Diseases
Necrosis Antibodies	>1 publications with STXBP1 and Necrosis

Organs/Tissues associated with anti-STXBP1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>64 publications with STXBP1 and Brain
Embryonic Tissue Antibodies	>10 publications with STXBP1 and Embryonic Tissue
Pancreas Antibodies	>8 publications with STXBP1 and Pancreas
Testis Antibodies	>3 publications with STXBP1 and Testis
Kidney Antibodies	>2 publications with STXBP1 and Kidney
Spinal Cord Antibodies	>2 publications with STXBP1 and Spinal Cord
Heart Antibodies	>2 publications with STXBP1 and Heart
Eye Antibodies	>2 publications with STXBP1 and Eye
Liver Antibodies	>2 publications with STXBP1 and Liver
Intestine Antibodies	>1 publications with STXBP1 and Intestine