Goat Anti-APOH Polyclonal Antibody – Cat# MBS512025

Beta2-Glycoprotein-1 (APO-H) (APOH) Antibody – Goat Polyclonal

Name: APOH Antibody; Polyclonal; Goat; MyBioSource
Brand: MyBioSource
SKU: MBS512025
Price: 540 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS512025

Apolipoprotein-H, also known as beta2-Glycoprotein I (beta2GPI), is a plasma glycoprotein that circulates at a concentration of 200 ug/ml (4 uM). Synthesized in the liver, beta2GPI is a single chain molecule of 48 kDa, consisting of five repeating internally… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

beta2-Glycoprotein-1 (APO-H) (APOH), Polyclonal Antibody

Full Product Name

Goat anti-human Apolipoprotein-H (beta2GPI), Peroxidase Conjugated IgG

Product Gene Name

anti-APOH antibody

Product Synonym Names

beta2-Glycoprotein-1 (APO-H), human

Clonality

Polyclonal

Host

Goat

Form/Format

IgG-HRP conjugate as a clear, slightly red-brown liquid.

Purity/Purification

Peroxidase conjugated IgG.
Vial containing ml of whole IgG conjugated to horseradish peroxidase (HRP) through carbohydrate groups. Total protein is 0.2 mg.

Concentration

IgG-HRP concentration is mg/ml, determined by absorbance using an extinction coefficient (E1%280) of 14. (lot specific)

Specificity

Prior to conjugation, this antibody was specific for beta2GPI as demonstrated by immunoelectrophoresis and ELISA.

Preparation and Storage

Store between -10 and -20 degree C. Product will become viscous but will not freeze. Avoid storage in frost-free freezers. Keep vial tightly capped. Allow product to warm to room temperature and gently mix before use. Avoid exposure to sodium azide as this is an inhibitor of peroxidase activity.

Molecular Weight

38,298 Da

Chromosome Location

Chromosome: 17; NC_000017.10 (64208147..64225556, complement). Location: 17q23-qter

OMIM

138700

3D Structure

ModBase 3D Structure for P02749

Immunogen

Human beta2GPI purified from plasma.

Buffer

A buffered stabilizer solution containing 50% (v/v) glycerol.

Application Notes for anti-APOH antibody

Suitable as a source of peroxidase-labelled antibodies to human beta2GPI.

Product References and Citations for anti-APOH antibody

1. Lee, NS, Brewer HB Jr., Osborne JC Jr.; beta2Glycoprotein I: Molecular Properties of an Unusual Apolipoprotein, Apolipoprotein H ; JBC 258, pp 4765-4770, 1983.
2. Schousboe I; beta2Glycoprotein I: A Plasma Inhibitor of the Contact Activation of the Intrinsic Blood Coagulation Pathway. Blood 66, p p 1086-1091, 1985.
3. Nimpf J, Bevers EM, Bomans PHH, Till U, Wurm H, Kostner GM, Zwaal RFA; Prothrombinase activity of human platelets is inhibited by beta2Glycoprotein I; Biochimica et Biophysica Acta 884, pp 142- 149, 1986.

Other Notes

Small volumes of anti-APOH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for APOH purchase

MBS512025 is an antibody targeting APOH. Also known as Goat anti-human Apolipoprotein-H (beta2GPI), Peroxidase Conjugated IgG. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for APOH. It may not necessarily be applicable to this product.

NCBI GI #

153266841

NCBI GeneID

350

NCBI Accession #

NP_000033.2

UniProt Primary Accession #

P02749

UniProt Secondary Accession #

Q9UCN7; B2R9M3

UniProt Related Accession #

P02749

GenBank Nucleotide #

NM_000042.2

NCBI Official Full Name

beta-2-glycoprotein 1

NCBI Official Synonym Full Names

apolipoprotein H (beta-2-glycoprotein I)

NCBI Official Symbol

APOH

NCBI Official Synonym Symbols

BG; B2G1; B2GP1

UniProt Protein Name

Beta-2-glycoprotein 1

UniProt Synonym Protein Names

APC inhibitor; Activated protein C-binding protein; Anticardiolipin cofactor; Apolipoprotein H; Apo-H; Beta-2-glycoprotein I

Protein Family

Beta-2-glycoprotein

UniProt Gene Name

APOH

UniProt Synonym Gene Names

B2G1

UniProt Entry Name

APOH_HUMAN

NCBI Protein Information

beta-2-glycoprotein 1; B2GPI; apo-H; beta(2)GPI; APC inhibitor; anticardiolipin cofactor; activated protein C-binding protein

NCBI Summary for APOH

Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq]

UniProt Comments for APOH

Function: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

Subcellular location: Secreted.

Tissue specificity: Expressed by the liver and secreted in plasma.

Post-translational modification: N- and O-glycosylated. Ref.10 also reports glycosylation on 'Asn-188' for their allele. Ref.10 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21

Sequence similarities: Contains 4 Sushi (CCP/SCR) domains.

Research Articles on APOH

1. Positive result in a beta2GPI-dependent lupus anticoagulant (LAC) assay correlates better with thrombosis than the classic LAC assay.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-APOH antibody

Reference Product	PubMed Publications
PLG antibody	>1 publications with APOH and PLG
LPA antibody	>1 publications with APOH and LPA

Diseases associated with anti-APOH antibody

Disease Name	Pubmed Publications
Vascular Diseases Antibodies	>16 publications with APOH and Vascular Diseases
Liver Diseases Antibodies	>7 publications with APOH and Liver Diseases
Myocardial Ischemia Antibodies	>6 publications with APOH and Myocardial Ischemia
Neoplasms Antibodies	>5 publications with APOH and Neoplasms
Inflammation Antibodies	>4 publications with APOH and Inflammation
Hemorrhage Antibodies	>4 publications with APOH and Hemorrhage
Hypertension Antibodies	>3 publications with APOH and Hypertension
Liver Neoplasms Antibodies	>3 publications with APOH and Liver Neoplasms
Atherosclerosis Antibodies	>3 publications with APOH and Atherosclerosis
Arteriosclerosis Antibodies	>3 publications with APOH and Arteriosclerosis

Organs/Tissues associated with anti-APOH antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>41 publications with APOH and Blood
Liver Antibodies	>19 publications with APOH and Liver
Brain Antibodies	>3 publications with APOH and Brain
Muscle Antibodies	>3 publications with APOH and Muscle
Lung Antibodies	>3 publications with APOH and Lung
Kidney Antibodies	>3 publications with APOH and Kidney
Intestine Antibodies	>2 publications with APOH and Intestine
Heart Antibodies	>2 publications with APOH and Heart
Spleen Antibodies	>1 publications with APOH and Spleen
Connective Tissue Antibodies	>1 publications with APOH and Connective Tissue