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Tissue Factor Pathway Inhibitor (TFPI) Antibody – Sheep Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS512162

MBS512162 is an antibody targeting TFPI. Also known as Sheep anti-human Tissue Factor Pathway Inhibitor (TFPI), Purified IgG. Host: Sheep. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
Tissue Factor Pathway Inhibitor (TFPI), Polyclonal Antibody
Full Product Name
Sheep anti-human Tissue Factor Pathway Inhibitor (TFPI), Purified IgG
Product Gene Name
Product Synonym Names
Tissue Factor Pathway Inhibitor, human
Clonality
Polyclonal
Host
Sheep
Purity/Purification
Purified IgG
Specificity
This antibody is specific for TFPI as demonstrated by immunoelectrophoresis and ELISA.
Preparation and Storage
Store between -10 and -20 degree C. Product will become viscous but will not freeze. Avoid storage in frost-free freezers. Keep vial tightly capped. Allow product to warm to room temperature and gently mix before use.
Molecular Weight
35,015 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (188328957..188419219, complement). Location: 2q32
OMIM
152310
3D Structure
ModBase 3D Structure for P10646
Immunogen
Synthetic peptide corresponding to NH-terminus of human TFPI conjugated to carrier.
Presentation
XXXX ml of immunoglobulin purified from sheep antiserum. The IgG concentration is XXXX mg/ml in 10 mM HEPES, pH 7.4, containing 0.15 M NaCl and 50% glycerol (v/v). Total protein is 10 mg.
Application Notes for anti-TFPI antibody
This product is suitable as a source of antibodies to TFPI.

Other Notes

Small volumes of anti-TFPI antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TFPI. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
Tissue factor pathway inhibitor
NCBI Official Synonym Full Names
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
NCBI Official Symbol
TFPI
NCBI Official Synonym Symbols
EPI; TFI; LACI; TFPI1
UniProt Protein Name
Tissue factor pathway inhibitor
UniProt Synonym Protein Names
Extrinsic pathway inhibitor; EPI; Lipoprotein-associated coagulation inhibitor
UniProt Gene Name
TFPI
UniProt Synonym Gene Names
LACI; TFPI1
UniProt Entry Name
TFPI1_HUMAN
NCBI Protein Information
tissue factor pathway inhibitor; anti-convertin; OTTHUMP00000163472; OTTHUMP00000205424; OTTHUMP00000205430; OTTHUMP00000205431; extrinsic pathway inhibitor; lipoprotein-associated coagulation inhibitor

NCBI Summary for TFPI

This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq]
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UniProt Comments for TFPI

Function: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.

Subcellular location: Secreted.

Tissue specificity: Mostly in endothelial cells.

Domain: This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa.

Post-translational modification: O-glycosylated. Ref.10 Ref.14 Ref.16

Sequence similarities: Contains 3 BPTI/Kunitz inhibitor domains.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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