Vitronectin (VTN) Antibody – Sheep Polyclonal

Vitronectin (Vn), previously known as serum-spreading factor or Sprotein, is a plasma and serum glycoprotein with a normal concentration ranging from 200 - 400 ug/ml. It exists in both a 75 kDa single-chain form and a 65 + 10 kDa two-chain form. Vn can exist in a least two different conformational forms. The majority of Vn found in the circulation is present in the native ("closed") form. In this form, most of the binding sites for other ligands are cryptic. The second form of Vn, the denatured ("open", multimeric) form, is a result of a conformational change in the native protein induced by denaturants such as urea, adsorption onto surfaces, low pH or reduction and alkylation. This conformational change leads to exposure of the heparin binding site, formation of disulfide-bonded multimers and rupture of the disulfide bond that links the 10 kDa light chain to the 65 kDa heavy chain of the two chain form. The liver is the primary site of vitronectin synthesis, however, Vn is also found in platelets, megakaryocytes, monocytes and macrophages. Vn plays an important role in a number of physiological and pathophysiological processes. It promotes the adhesion and spreading of a wide variety of cell types and is a subcomponent of the soluble SC5b-9 complex of complement where it protects bystander cells from cytolysis. Vn also plays an important role in fibrinolysis by stabilizing PAI-1 in its active conformation which otherwise rapidly converts to a latent form.1-3

Description: Vial containing 0.25 ml if IgG purified by affinity chromatography on immobilized vitronectin. Total protein is 0.5 mg. (lot specific).

1. Tomasini, B.R., and Mosher, D.F. Vitronectin. Prog. Hemost. Thromb., 10:269-305, 1991.
2. Hess, S., Stockmann, A., Voler, W., and Preissner, K.T. Multimeric vitronectin: structure and function. In: Biology of Vitronectins and their Receptors, Elsevier Science Publishers, Amsterdam, p. 21-29, 1993.
3. Preissner, K.T., and Jenne, D. Vitronectin: a new molecular connection in haemostasis. Thrombo. Haemost., 66(2):189-194, 1991.

Small volumes of anti-Vtn antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS512172 is an antibody targeting Vtn. Also known as Sheep anti-human Vitronectin, Peroxidase Conjugated Affinity-Purified IgG. Host: Sheep.