PAD1 Recombinant Protein

Name: PAD1 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS515126
Price: 345 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS515126

MBS515126 is a recombinant protein targeting PAD1. Host: Sf9 insect cells. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

PAD1, Recombinant Protein

Full Product Name

PAD1 recombinant protein

Product Gene Name

PAD1 recombinant protein

Product Synonym Names

HPAD10; PADI1; PDI; PDI1

Host

Sf9 insect cells

Form/Format

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation and Storage

Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight

95 kDa

Chromosome Location

Chromosome: 1; NC_000001.10 (17531621..17572501). Location: 1p36.13

OMIM

607934

3D Structure

ModBase 3D Structure for Q9ULC6

Type

Recombinant Fusion Protein

Species

Human

Tag Information

N-terminal GST

Source Note

Recombinant full-length human PAD1 was expressed by baculovirus in Sf9 insect cells

Product Categories/Family for PAD1 recombinant protein

Arginine Deiminases Proteins

Applications Tested/Suitable for PAD1 recombinant protein

Western Blot (WB)

Other Notes

Small volumes of PAD1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PAD1. It may not necessarily be applicable to this product.

NCBI GI #

122056684

NCBI GeneID

29943

NCBI Accession #

NP_037490.2

UniProt Primary Accession #

Q9ULC6

UniProt Secondary Accession #

Q70SX6; A1L4K6

UniProt Related Accession #

Q9ULC6

GenBank Nucleotide #

NM_013358

NCBI Official Full Name

Homo sapiens peptidyl arginine deiminase, type I (PADI1), mRNA

NCBI Official Synonym Full Names

peptidyl arginine deiminase, type I

NCBI Official Symbol

PADI1

NCBI Official Synonym Symbols

PDI; PAD1; PDI1; HPAD10

UniProt Protein Name

Protein-arginine deiminase type-1

UniProt Synonym Protein Names

Peptidylarginine deiminase I; Protein-arginine deiminase type I

Protein Family

Flavin prenyltransferase

UniProt Gene Name

PADI1

UniProt Synonym Gene Names

PDI1

UniProt Entry Name

PADI1_HUMAN

NCBI Protein Information

protein-arginine deiminase type-1; hPAD-colony 10; peptidylarginine deiminase I; protein-arginine deiminase type I

NCBI Summary for PAD1

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

UniProt Comments for PAD1

Function: Catalyzes the deimination of arginine residues of proteins

By similarity.

Catalytic activity: Protein L-arginine + H2O = protein L-citrulline + NH3.

Cofactor: Calcium

By similarity.

Subcellular location: Cytoplasm Ref.1.

Tissue specificity: Epidermis, prostate, testis, placenta, spleen and thymus. Ref.1

Sequence similarities: Belongs to the protein arginine deiminase family.

Research Articles on PAD1

1. NF-kappaB-mediated signaling pathway is involved in PADI1 regulation in human epidermal keratinocytes

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PAD1 recombinant protein

Products by Pathway	Pathway Diagram
Protein Citrullination Pathway antibodies	Protein Citrullination Pathway Diagram
Protein Citrullination Pathway antibodies	Protein Citrullination Pathway Diagram

Diseases associated with PAD1 recombinant protein

Disease Name	Pubmed Publications
Carcinoma, Squamous Cell Antibodies	>1 publications with PAD1 and Carcinoma, Squamous Cell
Neoplasms Antibodies	>1 publications with PAD1 and Neoplasms
Carcinoma Antibodies	>1 publications with PAD1 and Carcinoma

Organs/Tissues associated with PAD1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>2 publications with PAD1 and Skin
Mouth Antibodies	>1 publications with PAD1 and Mouth