The purity of KAT9 (ELP3) was determined to be >70% by densitometry. Approx. MW 86kDa.

KAT9 (ELP3) Recombinant Protein

Name: KAT9 (ELP3) Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS515148
Price: 350 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS515148

Recombinant full-length human KAT9 (ELP3) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_018091.KAT9 (also known as ELP3) is the catalytic subunit of the histone acetyltransferase (HAT) elongator… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

KAT9 (ELP3), Recombinant Protein

Full Product Name

KAT9 (ELP3) recombinant protein

Product Gene Name

KAT9 (ELP3) recombinant protein

Product Synonym Gene Name

KAT9; ELP3; FLJ10422

Product Synonym Names

KAT9; ELP3; FLJ10422; KAT9 (ELP3)

Form/Format

Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Purity/Purification

>70%

Concentration

0.1ug/ul (lot specific)

Preparation and Storage

Ships on Dry Ice.
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Chromosome Location

Chromosome: 8; NC_000008.10 (27950584..28048670). Location: 8p21.1

OMIM

612722

3D Structure

ModBase 3D Structure for Q9H9T3

Dry Ice Shipment

Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for KAT9 (ELP3) recombinant protein

Acetyl/Methyltransferases Proteins; Signaling Proteins - Acetyl/Methyltransferase Proteins

Other Notes

Small volumes of KAT9 (ELP3) recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KAT9 (ELP3) purchase

MBS515148 is a recombinant protein targeting KAT9 (ELP3).

Additional Details

NCBI/Uniprot data below describe general gene information for KAT9 (ELP3). It may not necessarily be applicable to this product.

NCBI GI #

187936940

NCBI GeneID

55140

NCBI Accession #

NP_060561.3

UniProt Primary Accession #

Q9H9T3

UniProt Secondary Accession #

Q53G84; Q6AWB0; Q9BVF7; Q9NVZ1

UniProt Related Accession #

Q9H9T3

GenBank Nucleotide #

NM_018091

NCBI Official Full Name

Homo sapiens elongator acetyltransferase complex subunit 3 (ELP3), transcript variant 1, mRNA

NCBI Official Synonym Full Names

elongator acetyltransferase complex subunit 3

NCBI Official Symbol

ELP3

NCBI Official Synonym Symbols

KAT9

UniProt Protein Name

Elongator complex protein 3

UniProt Gene Name

ELP3

UniProt Synonym Gene Names

hELP3

UniProt Entry Name

ELP3_HUMAN

NCBI Protein Information

elongator complex protein 3; elongation protein 3 homolog

NCBI Summary for KAT9 (ELP3)

ELP3 is the catalytic subunit of the histone acetyltransferase elongator complex, which contributes to transcript elongation and also regulates the maturation of projection neurons (Creppe et al., 2009 [PubMed 19185337]).[supplied by OMIM, Apr 2009]

UniProt Comments for KAT9 (ELP3)

Function: Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. May also have a methyltransferase activity. Involved in cell migration. Ref.5 Ref.6 Ref.7 Ref.9

Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Cofactor: Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine

By similarity.

Subunit structure: Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6. IKBKAP/ELP1, STIP1/ELP2 and ELP3 form the Elongator core complex. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with IKBKAP/ELP1. Ref.5 Ref.6 Ref.12

Subcellular location: Isoform 1: Nucleus Ref.5 Ref.6 Ref.12 Ref.13. Isoform 2: Cytoplasm. Nucleus Ref.5 Ref.6 Ref.12 Ref.13.

Sequence similarities: Belongs to the ELP3 family.Contains 1 N-acetyltransferase domain.

Sequence caution: The sequence BAA91600.1 differs from that shown. Reason: Aberrant splicing.The sequence CAH10573.1 differs from that shown. Reason: Frameshift at position 279.

Research Articles on KAT9 (ELP3)

1. data suggest that hElp3 can regulate the transcription of HSP70 gene, and the HAT domain of hElp3 is essential for this function

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with KAT9 (ELP3) recombinant protein

Reference Product	PubMed Publications
ELP4 recombinant protein	>10 publications with KAT9 (ELP3) and ELP4
ELP2 recombinant protein	>10 publications with KAT9 (ELP3) and ELP2
IKBKAP recombinant protein	>3 publications with KAT9 (ELP3) and IKBKAP

Diseases associated with KAT9 (ELP3) recombinant protein

Disease Name	Pubmed Publications
Atrophy Antibodies	>1 publications with KAT9 (ELP3) and Atrophy
Disease Models, Animal Antibodies	>1 publications with KAT9 (ELP3) and Disease Models, Animal

Organs/Tissues associated with KAT9 (ELP3) recombinant protein

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>18 publications with KAT9 (ELP3) and Nerve
Brain Antibodies	>5 publications with KAT9 (ELP3) and Brain
Embryonic Tissue Antibodies	>4 publications with KAT9 (ELP3) and Embryonic Tissue
Kidney Antibodies	>2 publications with KAT9 (ELP3) and Kidney
Lymph Antibodies	>1 publications with KAT9 (ELP3) and Lymph
Liver Antibodies	>1 publications with KAT9 (ELP3) and Liver
Lymph Node Antibodies	>1 publications with KAT9 (ELP3) and Lymph Node
Vascular Antibodies	>1 publications with KAT9 (ELP3) and Vascular
Uterus Antibodies	>1 publications with KAT9 (ELP3) and Uterus
Testis Antibodies	>1 publications with KAT9 (ELP3) and Testis