UHMK1 (KIS) Recombinant Protein

The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Function: Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA

By similarity.

Catalytic activity: ATP + a protein = ADP + a phosphoprotein.

Subunit structure: Interacts with stathmin and CDKN1B/p27Kip1

By similarity. Interacts with PAM. Ref.6 Ref.7

Subcellular location: Nucleus Ref.8.

Tissue specificity: Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes. Ref.7

Developmental stage: Regulated in a cell-cycle dependent manner, with lowest levels during S phase and highest at G1 phase (at protein level). Ref.8

Sequence similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.Contains 1 protein kinase domain.Contains 1 RRM (RNA recognition motif) domain.