IRAK3 Recombinant Protein

This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Function: Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex

By similarity. Ref.1

Catalytic activity: ATP + a protein = ADP + a phosphoprotein.

Cofactor: Magnesium. Ref.1

Tissue specificity: Expressed predominantly in peripheral blood lymphocytes. Ref.1

Involvement in disease: Asthma-related traits 5 (ASRT5) [MIM:611064]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.5

Sequence similarities: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.Contains 1 death domain.Contains 1 protein kinase domain.

Caution: Ser-293 is present instead of the conserved Asp which is expected to be an active site residue. Low level autophosphorylation activity has been reported in Ref.1, while other authors describe this as an inactive kinase.