CCNY Recombinant Protein – Cat# MBS515225

Cycliny (CCNY) Recombinant Protein

Name: CCNY Recombinant Protein; Cycliny; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS515225
Price: 350 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS515225

MBS515225 is a recombinant protein targeting CCNY. Also known as CyclinY recombinant protein. Host: Sf9 insect cells. More details

$350 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CyclinY (CCNY), Recombinant Protein

Full Product Name

CyclinY recombinant protein

Product Gene Name

CCNY recombinant protein

Product Synonym Names

CCNY; C10orf9; CBCP1; CCNX; CFP1; Cyclin Y Protein

Host

Sf9 insect cells

Form/Format

50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation and Storage

Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight

~65 kDa

Chromosome Location

Chromosome: 10; NC_000010.10 (35535953..35860848). Location: 10p11.21

OMIM

612786

3D Structure

ModBase 3D Structure for Q8ND76

Type

Recombinant Fusion Protein

Species

Human

Tag Information

N-terminal GST tag

Source Note

Recombinant human Cyclin Y (2-end) was expressed by baculovirus in Sf9 insect cells

Dry Ice Shipment

Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for CCNY recombinant protein

Cell Cycle Proteins

Applications Tested/Suitable for CCNY recombinant protein

Western Blot (WB)

Other Notes

Small volumes of CCNY recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CCNY. It may not necessarily be applicable to this product.

NCBI GI #

544583472

NCBI GeneID

219771

NCBI Accession #

NP_659449.3

UniProt Primary Accession #

Q8ND76

UniProt Secondary Accession #

Q2M3V4; Q2TU96; Q6NT86; Q7Z4U7; Q8TEX2; Q8TEX3; Q96M99; Q96P45; B7ZKX9; D3DRY9

UniProt Related Accession #

Q8ND76

GenBank Nucleotide #

NM_145012

NCBI Official Full Name

Homo sapiens cyclin Y (CCNY), transcript variant 1, mRNA

NCBI Official Synonym Full Names

cyclin Y

NCBI Official Symbol

CCNY

NCBI Official Synonym Symbols

CCNX; CFP1; CBCP1; C10orf9

UniProt Protein Name

Cyclin-Y

UniProt Synonym Protein Names

Cyclin box protein 1; Cyclin fold protein 1; cyclin-X

UniProt Gene Name

CCNY

UniProt Synonym Gene Names

C10orf9; CBCP1; CFP1; Cyc-Y

UniProt Entry Name

CCNY_HUMAN

NCBI Protein Information

cyclin-Y; cyc-Y; cyclin-X; cyclin box protein 1; cyclin fold protein 1; cyclin-box carrying protein 1

NCBI Summary for CCNY

Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2; MIM 116940) (Li et al., 2009 [PubMed 18060517]).[supplied by OMIM, May 2009]

UniProt Comments for CCNY

Function: Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. Ref.1 Ref.2 Ref.14 Ref.18

Subunit structure: Interacts with CDK14, CDK16 and LRP6. Ref.1 Ref.14 Ref.18

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side Ref.1 Ref.2 Ref.14 Ref.18. Isoform 3: Nucleus Ref.1 Ref.2 Ref.14 Ref.18.

Tissue specificity: Widely expressed. Ref.2

Developmental stage: Enriched at G2/M. Ref.14

Post-translational modification: Ubiquitinated; leading to its degradation. Ref.14

Sequence similarities: Belongs to the cyclin family. Cyclin Y subfamily.Contains 1 cyclin N-terminal domain.

Sequence caution: The sequence AAH69224.1 differs from that shown. Reason: Erroneous initiation.

Research Articles on CCNY

1. Cyclin Y regulates the expression and membrane trafficing of PCTAIRE kinases (PCTK). (Review)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with CCNY recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>9 publications with CCNY and Neoplasms
Cardiovascular Diseases Antibodies	>6 publications with CCNY and Cardiovascular Diseases
Crohn Disease Antibodies	>5 publications with CCNY and Crohn Disease
Colitis, Ulcerative Antibodies	>4 publications with CCNY and Colitis, Ulcerative
Breast Neoplasms Antibodies	>2 publications with CCNY and Breast Neoplasms
Lung Neoplasms Antibodies	>2 publications with CCNY and Lung Neoplasms
Learning Disorders Antibodies	>2 publications with CCNY and Learning Disorders
Inflammation Antibodies	>2 publications with CCNY and Inflammation
Cognition Disorders Antibodies	>2 publications with CCNY and Cognition Disorders
Melanoma Antibodies	>2 publications with CCNY and Melanoma

Organs/Tissues associated with CCNY recombinant protein

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>16 publications with CCNY and Eye
Lung Antibodies	>2 publications with CCNY and Lung