PTPRM (PTP- Mu) (PTPRM) Recombinant Protein

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Function: Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control. Ref.8

Catalytic activity: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location: Membrane; Single-pass type I membrane protein.

Sequence similarities: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.Contains 4 fibronectin type-III domains.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 MAM domain.Contains 2 tyrosine-protein phosphatase domains.