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OSR1 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS515319

Recombinant full-length human OSR1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: OSR1 is a member of the Ser/Thr family of protein kinases. OSR1 is activated by osmotic stresses and regulates the… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
OSR1, Recombinant Protein
Full Product Name
OSR1 recombinant protein
Product Gene Name
OSR1 recombinant protein
Product Synonym Gene Name
OXSR1; KIAA1101
Product Synonym Names
OXSR1; KIAA1101
Host
Sf9 insect cells
Form/Format
50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Preparation and Storage
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight
~86 kDa
Chromosome Location
Chromosome: 3; NC_000003.11 (38207022..38296979). Location: 3p22.2
OMIM
604046
3D Structure
ModBase 3D Structure for O95747
Type
Recombinant Fusion Protein
Species
Human
Tag Information
GST tag
Expression System
Sf9 insect cells using baculovirus
Source Note
Recombinant full-length human OSR1 was expressed by baculovirus in Sf9 insect cells
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for OSR1 recombinant protein

Cellular Proteins; Signaling Proteins - Cellular Proteins
Applications Tested/Suitable for OSR1 recombinant protein
Western Blot (WB)

SDS-PAGE of OSR1 recombinant protein

OSR1 Recombinant Protein – Cat# MBS515319

Product References and Citations for OSR1 recombinant protein

1. Chen W. et al: Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily. J. Biol. Chem. 279:11129-11136(2004).
2. Matsuoka S. et al: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316:1160-1166 (2007).

Other Notes

Small volumes of OSR1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OSR1 purchase

MBS515319 is a recombinant protein targeting OSR1. Host: Sf9 insect cells.

Additional Details

NCBI/Uniprot data below describe general gene information for OSR1. It may not necessarily be applicable to this product.

NCBI GI #
75709206
NCBI GeneID
9943
NCBI Accession #
NP_005100.1
UniProt Primary Accession #
O95747
UniProt Secondary Accession #
Q3LR53; Q7Z501; Q9UPQ1
UniProt Related Accession #
O95747
GenBank Nucleotide #
NM_005109
NCBI Official Full Name
Homo sapiens oxidative stress responsive 1 (OXSR1), mRNA
NCBI Official Synonym Full Names
oxidative stress responsive 1
NCBI Official Symbol
OXSR1
NCBI Official Synonym Symbols
OSR1
UniProt Protein Name
Serine/threonine-protein kinase OSR1
UniProt Synonym Protein Names
Oxidative stress-responsive 1 protein
Protein Family
Protein odd-skipped
UniProt Gene Name
OXSR1
UniProt Synonym Gene Names
KIAA1101; OSR1
UniProt Entry Name
OXSR1_HUMAN
NCBI Protein Information
serine/threonine-protein kinase OSR1; oxidative-stress responsive 1; oxidative stress-responsive 1 protein

NCBI Summary for OSR1

The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]

UniProt Comments for OSR1

Function: Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton. Ref.6

Catalytic activity: ATP + a protein = ADP + a phosphoprotein.

Cofactor: Magnesium.

Enzyme regulation: By autophosphorylation on threonine. Ref.6

Subunit structure: Binds to and phosphorylates PAK1. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. Binds to and phosphorylates RELL1, RELL2 AND RELT. Ref.6 Ref.7

Subcellular location: Cytoplasm Ref.17.

Tissue specificity: Ubiquitously expressed in all tissue examined. Ref.1

Sequence similarities: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Contains 1 protein kinase domain.

Sequence caution: The sequence AAP97192.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA83053.2 differs from that shown. Reason: Frameshift at position 63.
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Research Articles on OSR1

1. SPAK and OSR1, which are often coexpressed in cells, can form functional heterodimers.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with OSR1 recombinant protein

 Reference Product  PubMed Publications
 WNK1 recombinant protein  >8 publications with OSR1 and WNK1
 RELL1 recombinant protein  >2 publications with OSR1 and RELL1
 RELT recombinant protein  >2 publications with OSR1 and RELT
 PAK1 recombinant protein  >1 publications with OSR1 and PAK1
 RELL2 recombinant protein  >1 publications with OSR1 and RELL2
 PLSCR1 recombinant protein  >1 publications with OSR1 and PLSCR1

Diseases associated with OSR1 recombinant protein

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >6 publications with OSR1 and Hypertension
 Cardiovascular Diseases Antibodies  >2 publications with OSR1 and Cardiovascular Diseases
 Necrosis Antibodies  >2 publications with OSR1 and Necrosis
 Hyperkalemia Antibodies  >1 publications with OSR1 and Hyperkalemia
 Kidney Diseases Antibodies  >1 publications with OSR1 and Kidney Diseases
 Fibrosis Antibodies  >1 publications with OSR1 and Fibrosis
 Myocardial Infarction Antibodies  >1 publications with OSR1 and Myocardial Infarction
 Neoplasms Antibodies  >1 publications with OSR1 and Neoplasms
 Lung Neoplasms Antibodies  >1 publications with OSR1 and Lung Neoplasms

Organs/Tissues associated with OSR1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with OSR1 and Brain
 Blood Antibodies  >3 publications with OSR1 and Blood
 Kidney Antibodies  >2 publications with OSR1 and Kidney
 Prostate Antibodies  >2 publications with OSR1 and Prostate
 Heart Antibodies  >2 publications with OSR1 and Heart
 Nerve Antibodies  >2 publications with OSR1 and Nerve
 Intestine Antibodies  >1 publications with OSR1 and Intestine
 Liver Antibodies  >1 publications with OSR1 and Liver
 Pancreas Antibodies  >1 publications with OSR1 and Pancreas
 Skin Antibodies  >1 publications with OSR1 and Skin
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