RAC3 Recombinant Protein

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. [provided by RefSeq, Jul 2008]

Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Ref.6

Subunit structure: Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with C1D. Ref.5 Ref.6 Ref.7

Subcellular location: Cytoplasm. Endomembrane system. Cell projection › lamellipodium. Note: Membrane-associated when activated. Colocalizes with NRBP to endomembranes and at the cell periphery in lamellipodia. Ref.6

Tissue specificity: Highest levels in brain, also detected in heart, placenta and pancreas.

Induction: Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation.

Sequence similarities: Belongs to the small GTPase superfamily. Rho family.