Calmodulin1 (CALM1) Recombinant Protein

This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Function: Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Ref.21

Subunit structure: Interacts with MYO1C and RRAD. Interacts with MYO10

By similarity. Interacts with CEP97, CEP110, TTN/titin and SRY. Interacts with USP6; the interaction is calcium dependent. Interacts with CDK5RAP2. Interacts with SCN5A. Interacts with RYR1 and RYR2. Interacts with FCHO1. Ref.16 Ref.17 Ref.18 Ref.19 Ref.21 Ref.22 Ref.23 Ref.28 Ref.31

Subcellular location: Cytoplasm › cytoskeleton › spindle. Cytoplasm › cytoskeleton › spindle pole. Note: Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. Ref.21

Post-translational modification: Ubiquitination results in a strongly decreased activity

By similarity.Phosphorylation results in a decreased activity

By similarity.

Involvement in disease: Ventricular tachycardia, catecholaminergic polymorphic 4 (CPVT4) [MIM:614916]: An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.42

Miscellaneous: This protein has four functional calcium-binding sites.

Sequence similarities: Belongs to the calmodulin family.Contains 4 EF-hand domains.

Sequence caution: The sequence CAA36839.1 differs from that shown. Reason: Erroneous gene model prediction.