TFG-ALK Recombinant Protein

There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

TFG: Defects in TFG are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving TFG is found in thyroid papillary carcinomas. Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript.

Protein type: Adaptor/scaffold; Oncoprotein

Chromosomal Location of Human Ortholog: 3q12.2

Cellular Component: cytosol

Molecular Function: identical protein binding; protein binding; signal transducer activity

Biological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; positive regulation of I-kappaB kinase/NF-kappaB cascade

Disease: Neuropathy, Hereditary Motor And Sensory, Okinawa Type; Spastic Paraplegia 57, Autosomal Recessive