TPM3-ALK Recombinant Protein

Description: Recombinant human fusion protein TPM3 (1-258)-ALK (1058-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Scientific Background: ALK or CD246 is a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. CD246 plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. ALK-positive neoplasms represent a distinct entity because the morphology of the tumors is often neither anaplastic nor large cell and the tumors should be referred to as ALK lymphomas (1). CD246 has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. CD246 act as a driver of inflammation. TPM3-ALK fusion oncogene sufficiently induces lymphoma/leukemia disorders (2).

1. Benharroch, D.et.al: ALK-positive lymphoma: a single disease with a broad spectrum of morphology. Blood 91: 2076-2084, 1998. 2. Giuriato S. et al: Conditional TPM3-ALK and NPM-ALK transgenic mice develop reversible ALK-positive early B-cell lymphoma/leukemia. Blood. 2010 May 20; 115 (20): 4061-70.

Small volumes of TPM3-ALK recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS515449 is a recombinant protein targeting TPM3-ALK. Also known as TPM3-ALK Mutant, Active. Host: Sf9 insect cells using baculovirus.