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CDC42 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS515462

Description: Recombinant full length human CDC42 was expressed in E Coli cells using an N-dual GST/His tag.Scientific Background: CDC42 is a member of the Rho family of GTPases and is part of cellular pathways fundamental to growth, differentiation and… More details

$370 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CDC42, Recombinant Protein
Full Product Name
CDC42, Active
Product Gene Name
CDC42 recombinant protein
Product Synonym Gene Name
G25K; CDC42Hs
Host
E Coli
Form/Format
50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Preparation and Storage
Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight
~48 kDa
Sequence Positions
Full length
OMIM
M35543 mRNA
3D Structure
ModBase 3D Structure for P60953
Species
Human
Tag
GST/HIS
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for CDC42 recombinant protein

Enzymes; Active GTPases/ATPases
Applications Tested/Suitable for CDC42 recombinant protein
Enzyme Assay, Western Blot (WB)

Testing Data of CDC42 recombinant protein

CDC42 Recombinant Protein – Cat# MBS515462

Testing Data #2 of CDC42 recombinant protein

CDC42 Recombinant Protein, Testing Data #2 – Cat# MBS515462

Product References and Citations for CDC42 recombinant protein

1. Erickson, J.W. et al: Multiple roles for Cdc42 in cell regulation. Curr Opin Cell Biol. 2001 Apr;13 (2):153-7. 2. Narumyia, S. et al: A new look at Rho GTPases in cell cycle: role in kinetochore-microtubule attachment. Cell Cycle. 2004 Jul;3 (7):855-7.

Other Notes

Small volumes of CDC42 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDC42 purchase

MBS515462 is a recombinant protein targeting CDC42. Also known as CDC42, Active. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CDC42. It may not necessarily be applicable to this product.

NCBI GI #
89903013
NCBI GeneID
998
NCBI Accession #
NM_001791.3
UniProt Primary Accession #
P60953
UniProt Secondary Accession #
P21181; P25763; Q7L8R5; Q9UDI2
UniProt Related Accession #
P60953
GenBank Nucleotide #
NM_001791
NCBI Official Full Name
Homo sapiens cell division cycle 42 (CDC42), transcript variant 1, mRNA
NCBI Official Synonym Full Names
cell division cycle 42
NCBI Official Symbol
CDC42
NCBI Official Synonym Symbols
TKS; G25K; CDC42Hs
UniProt Protein Name
Cell division control protein 42 homolog
UniProt Synonym Protein Names
G25K GTP-binding protein
Protein Family
Cdc42
UniProt Gene Name
CDC42
NCBI Protein Information
cell division control protein 42 homolog

NCBI Summary for CDC42

The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]
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UniProt Comments for CDC42

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation ().
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Research Articles on CDC42

1. rapamycin inhibits the RhoA, Rac1, and Cdc42 activated by high glucose(HG). Thus, rapamycin shows an obvious protective effect on HG-induced Epithelial-mesenchymal transition, by inhibiting the activation of Rho GTPases (RhoA, Rac1, and Cdc42).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CDC42 recombinant protein

 Reference Product  PubMed Publications
 PAK1 recombinant protein  >295 publications with CDC42 and PAK1
 IQGAP1 recombinant protein  >111 publications with CDC42 and IQGAP1
 PAK2 recombinant protein  >79 publications with CDC42 and PAK2
 WASL recombinant protein  >75 publications with CDC42 and WASL
 TNK2 recombinant protein  >38 publications with CDC42 and TNK2
 BAIAP2 recombinant protein  >22 publications with CDC42 and BAIAP2
 PARD6A recombinant protein  >12 publications with CDC42 and PARD6A
 ARHGAP1 recombinant protein  >3 publications with CDC42 and ARHGAP1

Pathways associated with CDC42 recombinant protein

 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
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 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
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 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram

Diseases associated with CDC42 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >642 publications with CDC42 and Neoplasms
 Carcinoma Antibodies  >194 publications with CDC42 and Carcinoma
 Nervous System Diseases Antibodies  >129 publications with CDC42 and Nervous System Diseases
 Inflammation Antibodies  >112 publications with CDC42 and Inflammation
 Necrosis Antibodies  >82 publications with CDC42 and Necrosis
 Disease Models, Animal Antibodies  >78 publications with CDC42 and Disease Models, Animal
 Brain Diseases Antibodies  >67 publications with CDC42 and Brain Diseases
 Cardiovascular Diseases Antibodies  >67 publications with CDC42 and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >46 publications with CDC42 and Neoplasms, Experimental
 Liver Diseases Antibodies  >46 publications with CDC42 and Liver Diseases

Organs/Tissues associated with CDC42 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >543 publications with CDC42 and Blood
 Brain Antibodies  >437 publications with CDC42 and Brain
 Nerve Antibodies  >309 publications with CDC42 and Nerve
 Vascular Antibodies  >280 publications with CDC42 and Vascular
 Muscle Antibodies  >214 publications with CDC42 and Muscle
 Kidney Antibodies  >204 publications with CDC42 and Kidney
 Lung Antibodies  >156 publications with CDC42 and Lung
 Embryonic Tissue Antibodies  >153 publications with CDC42 and Embryonic Tissue
 Bone Antibodies  >126 publications with CDC42 and Bone
 Liver Antibodies  >104 publications with CDC42 and Liver
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