CDK11A Recombinant Protein

Name: CDK11A Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS515468
Price: 370 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS515468

Description: Recombinant human CDK11A (361-end) and full-length CyclinD3 were co-expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: CDK11A or cyclin-dependent kinase 11A is a member of the p34Cdc2 protein kinase… More details

$370 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CDK11A, Recombinant Protein

Full Product Name

CDK11A (CDC2L2)/CyclinD3 Protein

Product Gene Name

CDK11A recombinant protein

Product Synonym Gene Name

CDC2L2; CDC2L3; CDK11-p110; CDK11-p46

Host

Sf9 insect cells using baculovirus

Form/Format

50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation and Storage

Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight

~73 kDa; ~58 kDa

Sequence Positions

361-end (CDK11A) and Full length (CyclinD3)

OMIM

U04819 mRNA

Species

Human

Tag

GST tag

Dry Ice Shipment

Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for CDK11A recombinant protein

Signaling Proteins; Kinase Protein

Applications Tested/Suitable for CDK11A recombinant protein

Western Blot (WB)

Product References and Citations for CDK11A recombinant protein

1. Lahti, J. M. et.al: Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma. Nature Genet. 7: 370-375, 1994. 2. Loyer, P. et.al: Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection. J. Biol. Chem. 283: 7721-7732, 2008.

Other Notes

Small volumes of CDK11A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDK11A purchase

MBS515468 is a recombinant protein targeting CDK11A. Also known as CDK11A (CDC2L2)/CyclinD3 Protein. Host: Sf9 insect cells using baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for CDK11A. It may not necessarily be applicable to this product.

NCBI GI #

928589413

NCBI GeneID

728642

NCBI Accession #

NM_024011.3

UniProt Secondary Accession #

O95227; O95228; O96012; Q12821; Q12853; Q12854; Q2TAJ0; Q5QPR0; Q5QPR1; Q5QPR2; Q9UBC4

UniProt Related Accession #

Q9UQ88

GenBank Nucleotide #

NM_024011

NCBI Official Full Name

Homo sapiens cyclin dependent kinase 11A (CDK11A), transcript variant 1, mRNA

NCBI Official Synonym Full Names

cyclin dependent kinase 11A

NCBI Official Symbol

CDK11A

NCBI Official Synonym Symbols

CDC2L2; CDC2L3; p58GTA; PITSLRE; CDK11-p46; CDK11-p58; CDK11-p110

UniProt Protein Name

Cyclin-dependent kinase 11A

UniProt Synonym Protein Names

Cell division cycle 2-like protein kinase 2; Cell division protein kinase 11A; Galactosyltransferase-associated protein kinase p58/GTA; PITSLRE serine/threonine-protein kinase CDC2L2

Protein Family

Cyclin-dependent kinase

UniProt Gene Name

CDK11A

UniProt Synonym Gene Names

CDC2L2; CDC2L3; PITSLREB

NCBI Protein Information

cyclin-dependent kinase 11A

NCBI Summary for CDK11A

This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

UniProt Comments for CDK11A

CDK11A: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. The cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1. The p58 isoform but not the p110 isoform or p110C interacts with CCND3. The p110 isoforms are found in large molecular weight complexes containing CCNL1 and SFRS7. The p58 isoform is specifically induced in G2/M phase of the cell cycle. Expressed ubiquitously. Some evidence of isoform-specific tissue distribution. Phosphorylation at Thr-436 or Tyr-437 inactivates the enzyme, while phosphorylation at Thr-583 activates it. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: CDK family; CMGC group; Cell cycle regulation; EC 2.7.11.22; Kinase, protein; Motility/polarity/chemotaxis; PITSLRE subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); RNA processing

Chromosomal Location of Human Ortholog: 1p36.33

Cellular Component: nucleus

Molecular Function: ATP binding; cyclin-dependent protein kinase activity; protein serine/threonine kinase activity

Biological Process: protein amino acid phosphorylation; regulation of cell growth; regulation of mitotic cell cycle; regulation of mRNA processing

Research Articles on CDK11A

1. study identified p21 activated kinase 1 (PAK1) as a new CDK11(p58) substrate; mapped a new phosphorylation site of Ser174 on PAK1; results indicated PAK1 may serve as a downstream effector of CDK11(p58) during mitosis progression

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CDK11A recombinant protein

Products by Pathway	Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram
Centrosome Maturation Pathway antibodies	Centrosome Maturation Pathway Diagram
G2/M Transition Pathway antibodies	G2/M Transition Pathway Diagram
Mitotic G2-G2/M Phases Pathway antibodies	Mitotic G2-G2/M Phases Pathway Diagram
Recruitment Of Mitotic Centrosome Proteins And Complexes Pathway antibodies	Recruitment Of Mitotic Centrosome Proteins And Complexes Pathway Diagram

Diseases associated with CDK11A recombinant protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>5 publications with CDK11A and Necrosis
Carcinoma, Hepatocellular Antibodies	>2 publications with CDK11A and Carcinoma, Hepatocellular
Inflammation Antibodies	>2 publications with CDK11A and Inflammation
Fibrosis Antibodies	>1 publications with CDK11A and Fibrosis
Brain Diseases Antibodies	>1 publications with CDK11A and Brain Diseases

Organs/Tissues associated with CDK11A recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>6 publications with CDK11A and Liver
Blood Antibodies	>5 publications with CDK11A and Blood
Ovary Antibodies	>4 publications with CDK11A and Ovary
Connective Tissue Antibodies	>3 publications with CDK11A and Connective Tissue
Brain Antibodies	>3 publications with CDK11A and Brain
Skin Antibodies	>2 publications with CDK11A and Skin
Testis Antibodies	>2 publications with CDK11A and Testis
Eye Antibodies	>1 publications with CDK11A and Eye
Kidney Antibodies	>1 publications with CDK11A and Kidney
Pancreas Antibodies	>1 publications with CDK11A and Pancreas