CDK11 Recombinant Protein – Cat# MBS515483

CDK11/Cyclinc (CDK11) Recombinant Protein

Name: CDK11 Recombinant Protein; CDK11/Cyclinc; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS515483
Price: 370 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS515483

Description: Recombinant full-length human CDK11/CyclinC was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: CDK11/Cyclin C is a member of the p34Cdc2 protein kinase family which are known to be essential for… More details

$370 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CDK11/CyclinC, Recombinant Protein

Full Product Name

CDK11/CyclinC Protein

Product Gene Name

CDK11 recombinant protein

Product Synonym Gene Name

CDC2L6; CDK8-like; bA346C16.3; KIAA1028

Host

Sf9 insect cells using baculovirus

Form/Format

50mM Tris-HCl, pH 7.5, 50mM NaCl, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Preparation and Storage

Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight

~92 kDa; ~55 kDa

Sequence Positions

Full length

OMIM

AY028424 mRNA

3D Structure

ModBase 3D Structure for Q9BWU1

Species

Human

Tag

GST tag

Dry Ice Shipment

Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for CDK11 recombinant protein

Signaling Proteins; Kinase Protein

Applications Tested/Suitable for CDK11 recombinant protein

Enzyme Assay, Western Blot (WB)

Product References and Citations for CDK11 recombinant protein

1. Lahti, J. M.. et.al: Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma. Nature Genet. 7: 370-375, 1994. 2. Bunnell, B.et.al: Elevated expression of a p58 protein kinase leads to changes in the CHO cell cycle. Proc. Nat. Acad. Sci. 87: 7467-7471, 1990. Note: Erratum: Proc. Nat. Acad. Sci. 88: 2612 only, 1991.

Other Notes

Small volumes of CDK11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDK11 purchase

MBS515483 is a recombinant protein targeting CDK11. Also known as CDK11/CyclinC Protein. Host: Sf9 insect cells using baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for CDK11. It may not necessarily be applicable to this product.

NCBI GI #

666335595

NCBI GeneID

23097

NCBI Accession #

NM_015076.4

UniProt Primary Accession #

Q9BWU1

UniProt Secondary Accession #

Q5JQZ7; Q5JR00; Q8TC78; Q9UPX2

UniProt Related Accession #

Q9BWU1

GenBank Nucleotide #

NM_015076

NCBI Official Full Name

Homo sapiens cyclin dependent kinase 19 (CDK19), transcript variant 1, mRNA

NCBI Official Synonym Full Names

cyclin dependent kinase 19

NCBI Official Symbol

CDK19

NCBI Official Synonym Symbols

CDK11; CDC2L6; bA346C16.3

UniProt Protein Name

Cyclin-dependent kinase 19

UniProt Synonym Protein Names

CDC2-related protein kinase 6; Cell division cycle 2-like protein kinase 6; Cell division protein kinase 19; Cyclin-dependent kinase 11; Death-preventing kinase

Protein Family

Cyclin-dependent kinase

UniProt Gene Name

CDK19

UniProt Synonym Gene Names

CDC2L6; CDK11; KIAA1028

NCBI Protein Information

cyclin-dependent kinase 19

NCBI Summary for CDK11

This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

UniProt Comments for CDK11

CDK19: a protein that is one of the components of the Mediator coactivator complex. The Mediator complex is a multiprotein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. [provided by RefSeq, Jul 2008]

Protein type: CDK family; CDK8 subfamily; CMGC group; Cell cycle regulation; EC 2.7.11.22; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: cytosol; nucleus; Srb-mediator complex

Molecular Function: cyclin-dependent protein kinase activity

Biological Process: protein amino acid phosphorylation; regulation of mitotic cell cycle

Research Articles on CDK11

1. On stimulation of TLR9, CDK8/19 positively regulates inflammatory gene transcription in cooperation with NF-kappaB and C/EBPbeta.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CDK11 recombinant protein

Reference Product	PubMed Publications
CCNC recombinant protein	>8 publications with CDK11 and CCNC
MED13 recombinant protein	>4 publications with CDK11 and MED13
MED13L recombinant protein	>1 publications with CDK11 and MED13L

Pathways associated with CDK11 recombinant protein

Products by Pathway	Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies	Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
PPARA Activates Gene Expression Pathway antibodies	PPARA Activates Gene Expression Pathway Diagram
Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies	Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram
Transcriptional Regulation Of White Adipocyte Differentiation Pathway antibodies	Transcriptional Regulation Of White Adipocyte Differentiation Pathway Diagram

Diseases associated with CDK11 recombinant protein

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>5 publications with CDK11 and Breast Neoplasms
Immune System Diseases Antibodies	>3 publications with CDK11 and Immune System Diseases
Disease Models, Animal Antibodies	>3 publications with CDK11 and Disease Models, Animal
Inflammation Antibodies	>2 publications with CDK11 and Inflammation
Neurobehavioral Manifestations Antibodies	>1 publications with CDK11 and Neurobehavioral Manifestations
Nervous System Diseases Antibodies	>1 publications with CDK11 and Nervous System Diseases
Neoplasms, Experimental Antibodies	>1 publications with CDK11 and Neoplasms, Experimental

Organs/Tissues associated with CDK11 recombinant protein

Organ/Tissue Name	Pubmed Publications
Connective Tissue Antibodies	>3 publications with CDK11 and Connective Tissue
Bone Antibodies	>2 publications with CDK11 and Bone
Prostate Antibodies	>2 publications with CDK11 and Prostate
Brain Antibodies	>2 publications with CDK11 and Brain
Lymph Antibodies	>1 publications with CDK11 and Lymph
Nerve Antibodies	>1 publications with CDK11 and Nerve
Eye Antibodies	>1 publications with CDK11 and Eye
Lymph Node Antibodies	>1 publications with CDK11 and Lymph Node
Embryonic Tissue Antibodies	>1 publications with CDK11 and Embryonic Tissue