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DPY30 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS515491

Description: Recombinant full-length human DPY30 was expressed in E Coli cells using an N-terminal His tag.Scientific Background: As a core subunit of the SET1/MLL histone methyl-transferase complexes, DPY30 modulates H3K4 methylation in vitro, and directly… More details

$350 / 0.02 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DPY30, Recombinant Protein
Full Product Name
DPY30 Protein
Product Gene Name
DPY30 recombinant protein
Product Synonym Gene Name
Cps25; HDPY-30; Saf19
Host
E Coli
Form/Format
50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Preparation and Storage
Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight
20 kDa
Sequence Positions
Full length
OMIM
AF226998 mRNA
3D Structure
ModBase 3D Structure for Q9C005
Species
Human
Tag
HIS tag
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for DPY30 recombinant protein

Signaling Proteins; Acetyl/Methyltransferases
Applications Tested/Suitable for DPY30 recombinant protein
Enzyme Assay, Western Blot (WB)

Testing Data of DPY30 recombinant protein

DPY30 Recombinant Protein – Cat# MBS515491

Product References and Citations for DPY30 recombinant protein

1. Zilka, N., et al. Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. FEBS Lett. 2006; 508: 3582-3588. 2. Rial, A. et al: Calcium Dyshomeostasis in beta-Amyloid and Tau-bearing Skeletal Myotubes. J. Biol. Chem., 2004; 279: 3524-53532

Other Notes

Small volumes of DPY30 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DPY30 purchase

MBS515491 is a recombinant protein targeting DPY30. Also known as DPY30 Protein. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for DPY30. It may not necessarily be applicable to this product.

NCBI GI #
1007386460
NCBI GeneID
84661
NCBI Accession #
NM_032574.3
UniProt Primary Accession #
Q9C005
UniProt Secondary Accession #
D6W578
UniProt Related Accession #
Q9C005
GenBank Nucleotide #
NM_032574
NCBI Official Full Name
Homo sapiens dpy-30, histone methyltransferase complex regulatory subunit (DPY30), transcript variant 1, mRNA
NCBI Official Synonym Full Names
dpy-30, histone methyltransferase complex regulatory subunit
NCBI Official Symbol
DPY30
NCBI Official Synonym Symbols
Cps25; Saf19; HDPY-30
UniProt Protein Name
Protein dpy-30 homolog
UniProt Synonym Protein Names
Dpy-30-like protein; Dpy-30L
Protein Family
DPY30 domain-containing protein
UniProt Gene Name
DPY30
UniProt Synonym Gene Names
Dpy-30L
NCBI Protein Information
protein dpy-30 homolog

NCBI Summary for DPY30

This gene encodes an integral core subunit of the SET1/MLL family of H3K4 methyltransferases. The encoded protein directly controls cell cycle regulators and plays an important role in the proliferation and differentiation of human hematopoietic progenitor cells. [provided by RefSeq, Mar 2016]

UniProt Comments for DPY30

DPY30: As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. Belongs to the dpy-30 family.

Chromosomal Location of Human Ortholog: 2p22.3

Cellular Component: Golgi apparatus; histone methyltransferase complex; nucleoplasm; nucleus; trans-Golgi network

Molecular Function: histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; identical protein binding; protein binding; protein homodimerization activity

Biological Process: chromatin silencing at telomere; endosome transport; histone H3-K4 methylation
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Research Articles on DPY30

1. Dpy30 role in cellular reprogramming and its interactions with Set1 complex

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DPY30 recombinant protein

 Reference Product  PubMed Publications
 ASH2L recombinant protein  >16 publications with DPY30 and ASH2L
 WDR5 recombinant protein  >13 publications with DPY30 and WDR5
 RBBP5 recombinant protein  >13 publications with DPY30 and RBBP5
 SETD1A recombinant protein  >7 publications with DPY30 and SETD1A
 MLL2 recombinant protein  >3 publications with DPY30 and MLL2
 MLL3 recombinant protein  >3 publications with DPY30 and MLL3
 MLL4 recombinant protein  >2 publications with DPY30 and MLL4

Pathways associated with DPY30 recombinant protein

 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 PKMTs Methylate Histone Lysines Pathway antibodies  PKMTs Methylate Histone Lysines Pathway Diagram

Diseases associated with DPY30 recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Malformations Antibodies  >2 publications with DPY30 and Nervous System Malformations
 Kidney Diseases Antibodies  >1 publications with DPY30 and Kidney Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with DPY30 and Cell Transformation, Neoplastic
 Chromosome Breakage Antibodies  >1 publications with DPY30 and Chromosome Breakage

Organs/Tissues associated with DPY30 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >3 publications with DPY30 and Heart
 Bone Marrow Antibodies  >1 publications with DPY30 and Bone Marrow
 Bone Antibodies  >1 publications with DPY30 and Bone
 Blood Antibodies  >1 publications with DPY30 and Blood
 Kidney Antibodies  >1 publications with DPY30 and Kidney
 Embryonic Tissue Antibodies  >1 publications with DPY30 and Embryonic Tissue
 Stomach Antibodies  >1 publications with DPY30 and Stomach
 Brain Antibodies  >1 publications with DPY30 and Brain
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