PAK1 Recombinant Protein

This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

PAK1: a protein kinase of the STE20 family that regulates cell motility and morphology. Critical RhoGTPase effector that regulates cytoskeleton reorganization, the JNK MAPK pathway, and nuclear signaling. Binding of Rac/cdc42 to the PBD of PAK1 causes autophosphorylation and conformational change. Phosphorylated and activated by PDK.

Protein type: EC 2.7.11.1; Kinase, protein; PAKA subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family

Chromosomal Location of Human Ortholog: 11q13.5-q14.1

Cellular Component: axon; cytoplasm; cytosol; dendrite; intercellular junction; nuclear membrane; plasma membrane; protein complex; ruffle; Z disc

Molecular Function: collagen binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; Rac GTPase binding

Biological Process: actin cytoskeleton reorganization; activation of protein kinase activity; branching morphogenesis of a tube; ephrin receptor signaling pathway; hepatocyte growth factor receptor signaling pathway; MAPKKK cascade; neurite morphogenesis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of estrogen receptor signaling pathway; positive regulation of JNK activity; positive regulation of microtubule polymerization; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of stress fiber formation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of axonogenesis; regulation of mitotic cell cycle; Rho protein signal transduction; stimulatory C-type lectin receptor signaling pathway; T cell costimulation; T cell receptor signaling pathway; wound healing