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PCTK1 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS515565

Description: Recombinant human PCTK1 (CDK16) (107-end) and Cyclin Y (2-end) were co-expressed by baculovirus in Sf9 insect cells using N-terminal GST tags.Scientific Background: PCTK1 or PCTAIRE PROTEIN KINASE 1 belongs to the cdc2/cdkx subfamily of the… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PCTK1, Recombinant Protein
Full Product Name
PCTK1 (CDK16)/CyclinY, Active
Product Gene Name
PCTK1 recombinant protein
Product Synonym Gene Name
FLJ16665; PCTAIRE; PCTAIRE1; PCTGAIRE
Host
Sf9 insect cells using baculovirus
Form/Format
50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Preparation and Storage
Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight
~ 66kDa; ~ 64kDa
Sequence Positions
PCTK1 (CDK16) (107-end) and Cyclin Y (2-end)
OMIM
X66363 mRNA
3D Structure
ModBase 3D Structure for Q00536
Species
Human
Tag
GST tag
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for PCTK1 recombinant protein

Enzymes; Active Kinases
Applications Tested/Suitable for PCTK1 recombinant protein
Kinase Assay, Western Blot (WB)

Testing Data of PCTK1 recombinant protein

PCTK1 Recombinant Protein – Cat# MBS515565

Testing Data #2 of PCTK1 recombinant protein

PCTK1 Recombinant Protein, Testing Data #2 – Cat# MBS515565

Product References and Citations for PCTK1 recombinant protein

1. Meyerson, M. et.al: A family of human cdc2-related protein kinases. EMBO J. 11: 2909-2917, 1992. 2. Knight, J. C. et.al: Physical linkage of the cdc2-related gene (PCTK1) and the ubiquitin-activating enzyme E1 gene (UBE1) on human Xp11.3. Cytogenet. Cell Genet. 71: 155-157, 1995.

Other Notes

Small volumes of PCTK1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PCTK1 purchase

MBS515565 is a recombinant protein targeting PCTK1. Also known as PCTK1 (CDK16)/CyclinY, Active. Host: Sf9 insect cells using baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for PCTK1. It may not necessarily be applicable to this product.

NCBI GI #
281427156
NCBI GeneID
5127
NCBI Accession #
NM_006201.4
UniProt Primary Accession #
Q00536
UniProt Secondary Accession #
A8K280; B7Z7C8; J3KN74; J3KQP7
UniProt Related Accession #
Q00536
GenBank Nucleotide #
NM_006201
NCBI Official Full Name
Homo sapiens cyclin dependent kinase 16 (CDK16), transcript variant 1, mRNA
NCBI Official Synonym Full Names
cyclin dependent kinase 16
NCBI Official Symbol
CDK16
NCBI Official Synonym Symbols
PCTK1; PCTAIRE; PCTAIRE1; PCTGAIRE
UniProt Protein Name
Cyclin-dependent kinase 16
UniProt Synonym Protein Names
Cell division protein kinase 16; PCTAIRE-motif protein kinase 1; Serine/threonine-protein kinase PCTAIRE-1
UniProt Gene Name
CDK16
UniProt Synonym Gene Names
PCTAIRE1; PCTK1
NCBI Protein Information
cyclin-dependent kinase 16

NCBI Summary for PCTK1

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]
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UniProt Comments for PCTK1

CDK16: an atypical member of the cyclin-dependent kinase (CDK) family. Activated via binding phosphorylated cyclin Y complexed with 14-3-3 zeta, theta, or eta. Plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development. Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Three isoforms of the human protein may be generated via alternative splicing.

Protein type: CDK family; CDK/TAIRE subfamily; CMGC group; Cell cycle regulation; EC 2.7.11.22; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); TAIRE subfamily

Chromosomal Location of Human Ortholog: Xp11.3

Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; microtubule cytoskeleton; nucleus; plasma membrane; synaptic vesicle

Molecular Function: cyclin-dependent protein kinase activity; protein binding; protein serine/threonine kinase activity

Biological Process: exocytosis; growth hormone secretion; neurite development; spermatogenesis
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Research Articles on PCTK1

1. CDK-16 upregulation in serous EOC cells may represent a negative feedback loop to promote ovarian cell differentiation in malignantly-transformed serous epithelial ovarian cancer cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with PCTK1 recombinant protein

 Disease Name  Pubmed Publications
 Infertility, Female Antibodies  >1 publications with PCTK1 and Infertility, Female
 Infertility, Male Antibodies  >1 publications with PCTK1 and Infertility, Male

Organs/Tissues associated with PCTK1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with PCTK1 and Brain
 Testis Antibodies  >2 publications with PCTK1 and Testis
 Epididymis Antibodies  >1 publications with PCTK1 and Epididymis
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