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PRMT3 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS515600

Description: Recombinant full-length human PRMT3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: PRMT3 is a protein arginine methyltransferase that catalyze the formation of asymmetric N (G),N… More details

$505 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PRMT3, Recombinant Protein
Full Product Name
PRMT3, Active
Product Gene Name
PRMT3 recombinant protein
Product Synonym Gene Name
HRMT1L3
Host
Sf9 insect cells using baculovirus
Form/Format
50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Preparation and Storage
Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight
~97 kDa
Sequence Positions
Full Length
OMIM
AK300591 mRNA
Species
Human
Tag
GST tag
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for PRMT3 recombinant protein

Enzymes; Active Methyltransferases
Applications Tested/Suitable for PRMT3 recombinant protein
Methyltransferase Assay

Testing Data of PRMT3 recombinant protein

PRMT3 Recombinant Protein – Cat# MBS515600

Testing Data #2 of PRMT3 recombinant protein

PRMT3 Recombinant Protein, Testing Data #2 – Cat# MBS515600

Product References and Citations for PRMT3 recombinant protein

1. Tang, J. et al: PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation. J. Biol. Chem. 273: 16935-16945, 1998. 2. Singh V, DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo. Oncogene. 2004 Oct 14;23 (47):7761-71.

Other Notes

Small volumes of PRMT3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRMT3 purchase

MBS515600 is a recombinant protein targeting PRMT3. Also known as PRMT3, Active. Host: Sf9 insect cells using baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for PRMT3. It may not necessarily be applicable to this product.

NCBI GI #
40674147
NCBI GeneID
10196
NCBI Accession #
BC064831
UniProt Secondary Accession #
B4DUC7
UniProt Related Accession #
O60678
NCBI Official Full Name
Homo sapiens protein arginine methyltransferase 3, mRNA
NCBI Official Synonym Full Names
protein arginine methyltransferase 3
NCBI Official Symbol
PRMT3
NCBI Official Synonym Symbols
HRMT1L3
UniProt Protein Name
Protein arginine N-methyltransferase 3
UniProt Synonym Protein Names
Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3
Protein Family
Probable protein arginine N-methyltransferase
UniProt Gene Name
PRMT3
UniProt Synonym Gene Names
HRMT1L3
NCBI Protein Information
protein arginine N-methyltransferase 3

NCBI Summary for PRMT3

This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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UniProt Comments for PRMT3

PRMT3: Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins. Belongs to the protein arginine N-methyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; EC 2.1.1.-; Methyltransferase; Methyltransferase, protein arginine

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: cytosol

Molecular Function: histone-arginine N-methyltransferase activity; methyltransferase activity; protein binding; protein-arginine N-methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity

Biological Process: negative regulation of protein ubiquitination; protein amino acid methylation; regulation of transcription, DNA-dependent
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Research Articles on PRMT3

1. Findings uncover the existence of an extra-ribosomal complex consisting of PDCD2L, RPS2, and PRMT3 and support a role for PDCD2L in the late maturation of 40S ribosomal subunits.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PRMT3 recombinant protein

 Reference Product  PubMed Publications
 PRMT5 recombinant protein  >15 publications with PRMT3 and PRMT5
 RPS2 recombinant protein  >10 publications with PRMT3 and RPS2
 PABPN1 recombinant protein  >2 publications with PRMT3 and PABPN1
 PDCD2L recombinant protein  >1 publications with PRMT3 and PDCD2L

Pathways associated with PRMT3 recombinant protein

 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Protein Methylation Pathway antibodies  Protein Methylation Pathway Diagram
 RMTs Methylate Histone Arginines Pathway antibodies  RMTs Methylate Histone Arginines Pathway Diagram

Diseases associated with PRMT3 recombinant protein

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >3 publications with PRMT3 and Breast Neoplasms
 Death Antibodies  >3 publications with PRMT3 and Death
 Lung Neoplasms Antibodies  >3 publications with PRMT3 and Lung Neoplasms
 Liver Diseases Antibodies  >2 publications with PRMT3 and Liver Diseases
 Fatty Liver Antibodies  >2 publications with PRMT3 and Fatty Liver
 Hypertension Antibodies  >2 publications with PRMT3 and Hypertension
 Heart Diseases Antibodies  >1 publications with PRMT3 and Heart Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with PRMT3 and Cell Transformation, Neoplastic
 Fibrosis Antibodies  >1 publications with PRMT3 and Fibrosis
 Kidney Diseases Antibodies  >1 publications with PRMT3 and Kidney Diseases

Organs/Tissues associated with PRMT3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with PRMT3 and Brain
 Lung Antibodies  >5 publications with PRMT3 and Lung
 Liver Antibodies  >4 publications with PRMT3 and Liver
 Vascular Antibodies  >3 publications with PRMT3 and Vascular
 Muscle Antibodies  >3 publications with PRMT3 and Muscle
 Blood Antibodies  >3 publications with PRMT3 and Blood
 Intestine Antibodies  >2 publications with PRMT3 and Intestine
 Embryonic Tissue Antibodies  >2 publications with PRMT3 and Embryonic Tissue
 Bone Antibodies  >1 publications with PRMT3 and Bone
 Skin Antibodies  >1 publications with PRMT3 and Skin
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