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PDE1C Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS515626

Description: Full-length recombinant human PDE1C was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: PDE1C is a member of the phosphodiesterases (PDE) family which catalyzes the hydrolysis of cyclic nucleotides… More details

$505 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PDE1C, Active Protein
Full Product Name
PDE1C, Active
Product Gene Name
PDE1C active protein
Product Synonym Gene Name
Hcam3
Host
Sf9 cells
Form/Format
Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Purity/Purification
>90%
Concentration
0.1 ug/ul (lot specific)
Specificity
Full length recombinant protein expressed in Sf9 cells
Preparation and Storage
Shipping: Dry Ice
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight
~99 kDa
OMIM
U40371 mRNA
3D Structure
ModBase 3D Structure for Q14123
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Specific Activity
445 nmol/min/mg
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for PDE1C active protein

Enzymes; Active Phosphodiesterases

Testing Data of PDE1C active protein

The specific activity of PDE1C was determined to be 445 nmol/min/mg as per activity assay protocol
PDE1C Active Protein – Cat# MBS515626

Testing Data #2 of PDE1C active protein

The purity of PDE1C was determined to be >90% by densitometry. Approx MW 99kDa
PDE1C Active Protein, Testing Data #2 – Cat# MBS515626

Product References and Citations for PDE1C active protein

1. Loughney, K. et al: Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3-prime, 5-prime-cyclic nucleotide phosphodiesterases. J. Biol. Chem. 271: 796-806, 1996. 2. Vandeput, F. et al; Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes. J. Biol. Chem. 282: 32749-42757, 2007.

Other Notes

Small volumes of PDE1C active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDE1C purchase

MBS515626 is an active protein targeting PDE1C. Also known as PDE1C, Active. Host: Sf9 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for PDE1C. It may not necessarily be applicable to this product.

NCBI GI #
1015120667
NCBI GeneID
5137
NCBI Accession #
NM_005020.4
UniProt Primary Accession #
Q14123
UniProt Secondary Accession #
Q14124; Q8NB10; B3KPC6; E9PE92
UniProt Related Accession #
Q14123
GenBank Nucleotide #
NM_005020
NCBI Official Full Name
Homo sapiens phosphodiesterase 1C (PDE1C), transcript variant 4, mRNA
NCBI Official Synonym Full Names
phosphodiesterase 1C
NCBI Official Symbol
PDE1C
NCBI Official Synonym Symbols
Hcam3; hCam-3; cam-PDE 1C
UniProt Protein Name
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
UniProt Synonym Protein Names
hCam-3
Protein Family
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase
UniProt Gene Name
PDE1C
UniProt Synonym Gene Names
Cam-PDE 1C
NCBI Protein Information
calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

NCBI Summary for PDE1C

This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016]
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UniProt Comments for PDE1C

PDE1C: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase

Chromosomal Location of Human Ortholog: 7p14.3

Cellular Component: cytosol

Molecular Function: calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
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Research Articles on PDE1C

1. PDE1C is a proliferation-associated gene in glioblastoma multiforme cells in vitro.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PDE1C active protein

 Products by Pathway  Pathway Diagram
 Ca-dependent Events Pathway antibodies  Ca-dependent Events Pathway Diagram
 CaM Pathway antibodies  CaM Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calmodulin Induced Events Pathway antibodies  Calmodulin Induced Events Pathway Diagram
 Cam-PDE 1 Activation Pathway antibodies  Cam-PDE 1 Activation Pathway Diagram
 DAG And IP3 Signaling Pathway antibodies  DAG And IP3 Signaling Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram

Diseases associated with PDE1C active protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >15 publications with PDE1C and Cardiovascular Diseases
 Hypertension Antibodies  >13 publications with PDE1C and Hypertension
 Hypertrophy Antibodies  >8 publications with PDE1C and Hypertrophy
 Lung Diseases Antibodies  >7 publications with PDE1C and Lung Diseases
 Cardiomegaly Antibodies  >4 publications with PDE1C and Cardiomegaly
 Fibrosis Antibodies  >4 publications with PDE1C and Fibrosis
 Mental Disorders Antibodies  >3 publications with PDE1C and Mental Disorders
 Hyperplasia Antibodies  >2 publications with PDE1C and Hyperplasia
 Disease Models, Animal Antibodies  >2 publications with PDE1C and Disease Models, Animal
 Male Urogenital Diseases Antibodies  >2 publications with PDE1C and Male Urogenital Diseases

Organs/Tissues associated with PDE1C active protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >20 publications with PDE1C and Brain
 Kidney Antibodies  >5 publications with PDE1C and Kidney
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